protein coding gene - cdc11 (SPCC1739.11c) - SIN component scaffold protein, centriolin ortholog Cdc11

Gene summary

Standard name

cdc11

Systematic ID

SPCC1739.11c

Product

SIN component scaffold protein, centriolin ortholog Cdc11

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74473

ORFeome ID

30/30B01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 2049130..2052603 reverse strand

Annotation

Protein features

Orthologs

• CNTRL (HGNC:1858) Homo sapiens
• cdc11 (SJAG_01188) Schizosaccharomyces japonicus
• NUD1 (YOR373W) Saccharomyces cerevisiae

References / Literature

PMID:16085489 - The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.

Mishra M et al. Curr Biol 2005 Aug 09;15(15):1376-83

PMID:24920823 - Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.

Rachfall N et al. Mol Biol Cell 2014 Aug 01;25(15):2250-9

PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.

Hanna SM et al. G3 (Bethesda) 2024 Oct 29;

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:22419817 - The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.

Feoktistova A et al. Mol Biol Cell 2012 May;23(9):1636-45

PMID:18411246 - Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation.

Ohtaka A et al. J Cell Sci 2008 May 01;121(Pt 9):1547-58

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:9786952 - imp2, a new component of the actin ring in the fission yeast Schizosaccharomyces pombe.

Demeter J et al. J Cell Biol 1998 Oct 19;143(2):415-27

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:16772338 - The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.

Martín-García R et al. J Cell Sci 2006 Jul 01;119(Pt 13):2768-79

PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.

Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6

PMID:12242222 - The Scw1 RNA-binding domain protein regulates septation and cell-wall structure in fission yeast.

Karagiannis J et al. Genetics 2002 Sep;162(1):45-58

PMID:10805785 - Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.

Chang L et al. Proc Natl Acad Sci U S A 2000 May 09;97(10):5249-54

PMID:39509469 - Rho1 and Rgf1 establish a new actin-dependent signal to determine growth poles in yeast independently of microtubules and the Tea1-Tea4 complex.

Garcia P et al. PLoS Biol 2024 Nov 07;22(11):e3002491

PMID:16775007 - Ppc89 links multiple proteins, including the septation initiation network, to the core of the fission yeast spindle-pole body.

Rosenberg JA et al. Mol Biol Cell 2006 Sep;17(9):3793-805

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:16787941 - The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.

Krapp A et al. J Cell Sci 2006 Jul 15;119(Pt 14):2882-91

PMID:15517003 - Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast.

Takeda T et al. Nat Cell Biol 2004 Nov;6(11):1142-4

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:38865179 - Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain.

Willet AH et al. Mol Biol Cell 2024 Jun 12;:mbcE24040196

PMID:10799520 - Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.

Li C et al. J Biol Chem 2000 May 12;275(19):14381-7

PMID:7634333 - The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis.

Fankhauser C et al. Cell 1995 Aug 11;82(3):435-44

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:12796296 - Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe.

Jin QW et al. Eukaryot Cell 2003 Jun;2(3):510-20

PMID:20970338 - Fission yeast Mto1 regulates diversity of cytoplasmic microtubule organizing centers.

Samejima I et al. Curr Biol 2010 Nov 09;20(21):1959-65

PMID:2203537 - The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene.

Uzawa S et al. Cell 1990 Sep 07;62(5):913-25

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:9398685 - Identification of a second myosin-II in Schizosaccharomyces pombe: Myp2p is conditionally required for cytokinesis.

Bezanilla M et al. Mol Biol Cell 1997 Dec;8(12):2693-705

PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.

Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477

PMID:9372443 - Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton.

Arellano M et al. J Cell Sci 1997 Oct;110 ( Pt 20):2547-55

PMID:20876564 - Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Lahoz A et al. Genetics 2010 Dec;186(4):1261-70

PMID:8978670 - Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.

Balasubramanian MK et al. EMBO J 1996 Dec 02;15(23):6426-37

PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Hirano T et al. EMBO J 1986 Nov;5(11):2973-9

PMID:10837231 - Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast.

Hou MC et al. Curr Biol 2000 May 18;10(10):619-22

PMID:11950932 - The spindle pole body protein Cdc11p links Sid4p to the fission yeast septation initiation network.

Tomlin GC et al. Mol Biol Cell 2002 Apr;13(4):1203-14

PMID:12446769 - The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.

Salus SS et al. Mol Cell Biol 2002 Dec;22(24):8491-505

PMID:11707284 - The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.

Le Goff X et al. FEBS Lett 2001 Nov 09;508(1):136-42

PMID:11739799 - Localization of fission yeast type II myosin, Myo2, to the cytokinetic actin ring is regulated by phosphorylation of a C-terminal coiled-coil domain and requires a functional septation initiation network.

Mulvihill DP et al. Mol Biol Cell 2001 Dec;12(12):4044-53

PMID:15957215 - Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis.

Uemura T et al. EMBO J 1986 May;5(5):1003-10

PMID:10459013 - Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.

Sparks CA et al. J Cell Biol 1999 Aug 23;146(4):777-90

PMID:22905165 - The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p.

Sharifmoghadam MR et al. PLoS One 2012;7(8):e42726

PMID:23966468 - Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.

Zhu YH et al. Mol Biol Cell 2013 Oct;24(20):3187-204

PMID:21131906 - Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.

Johnson AE et al. EMBO J 2011 Jan 19;30(2):341-54

PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.

Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:2229195 - Continued DNA synthesis after a mitotic block in the double mutant cut1 cdc11 of the fission yeast Schizosaccharomyces pombe.

Creanor J et al. J Cell Sci 1990 Jul;96 ( Pt 3):435-8

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388

PMID:11683392 - Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

Cueille N et al. J Cell Sci 2001 Jul;114(Pt 14):2649-64

PMID:12546793 - Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.

Krapp A et al. Curr Biol 2003 Jan 21;13(2):168-72

PMID:18562696 - The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast.

Yan H et al. Mol Biol Cell 2008 Sep;19(9):3676-90

PMID:22740629 - α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly.

Laporte D et al. Mol Biol Cell 2012 Aug;23(16):3094-110

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.

Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:20980623 - A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast.

Li WZ et al. Mol Biol Cell 2010 Dec;21(24):4349-60

PMID:15062098 - Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.

Morrell JL et al. Curr Biol 2004 Apr 06;14(7):579-84

PMID:15936270 - Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.

Tatebe H et al. Curr Biol 2005 Jun 07;15(11):1006-15

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:24047983 - Measuring affinities of fission yeast spindle pole body proteins in live cells across the cell cycle.

McCormick CD et al. Biophys J 2013 Sep 17;105(6):1324-35

PMID:1527180 - Genetic interactions in the control of septation in Schizosaccharomyces pombe.

Marks J et al. J Cell Sci 1992 Apr;101 ( Pt 4):801-8

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:10775265 - The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.

Guertin DA et al. EMBO J 2000 Apr 17;19(8):1803-15

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:9182666 - Fission yeast dim1(+) encodes a functionally conserved polypeptide essential for mitosis.

Berry LD et al. J Cell Biol 1997 Jun 16;137(6):1337-54

PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.

Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:10769201 - The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Salimova E et al. J Cell Sci 2000 May;113 ( Pt 10):1695-704

PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.

Pardo M et al. Science 2003 Jun 06;300(5625):1569-74

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:8039497 - The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.

Fankhauser C et al. EMBO J 1994 Jul 01;13(13):3011-9

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:9203579 - The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.

Schmidt S et al. Genes Dev 1997 Jun 15;11(12):1519-34

PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.

Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9254700 - Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein.

Schmidt S et al. Nucleic Acids Res 1997 Sep 01;25(17):3433-9

PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.

Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:8065367 - Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase.

Samejima I et al. Mol Cell Biol 1994 Sep;14(9):6361-71

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8313892 - The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb.

Ohi R et al. EMBO J 1994 Jan 15;13(2):471-83

PMID:11676915 - S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.

Krapp A et al. Curr Biol 2001 Oct 16;11(20):1559-68

PMID:24838944 - Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe.

Krapp A et al. J Cell Sci 2014 Jul 15;127(Pt 14):3149-61

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:40027523 - Characterization and comparison of temperature-sensitive Schizosaccharomyces pombe mutants of the septation initiation network scaffolds, Cdc11 and Sid4.

Turner LA et al. MicroPubl Biol 2025;2025

PMID:12007420 - Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe.

Arellano M et al. Curr Biol 2002 Apr 30;12(9):751-6

PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.

Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:23874188 - Dynamics of SIN asymmetry establishment.

Bajpai A et al. PLoS Comput Biol 2013;9(7):e1003147

PMID:11533255 - Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network.

Chang L et al. Mol Cell Biol 2001 Oct;21(19):6681-94

PMID:30928696 - Distinct Roles of Myosin-II Isoforms in Cytokinesis under Normal and Stressed Conditions.

Okada H et al. iScience 2019 Apr 26;14:69-87

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:15132994 - Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity.

Grallert A et al. Genes Dev 2004 May 01;18(9):1007-21

PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Fang Y et al. Genes Cells 2009 Jun;14(6):759-71

PMID:10462526 - The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited.

Beltraminelli N et al. J Cell Sci 1999 Sep;112 Pt 18:3103-14

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11271422 - Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.

Fournier N et al. Arch Microbiol 2001 Jan;175(1):62-9

PMID:12354095 - Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.

Lu Y et al. Genes Cells 2002 Oct;7(10):1009-19

PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.

Snell V et al. EMBO J 1994 May 01;13(9):2066-74

PMID:18256290 - Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.

Pinar M et al. Mol Biol Cell 2008 Apr;19(4):1727-38

PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.

Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424

PMID:22298427 - Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.

Ye Y et al. Mol Biol Cell 2012 Apr;23(7):1181-95

PMID:35099006 - Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway.

Sinha D et al. J Cell Sci 2022 Feb 15;135(4)

PMID:10924454 - A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.

Cullen CF et al. Genetics 2000 Aug;155(4):1521-34

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:8978688 - Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

Funabiki H et al. EMBO J 1996 Dec 02;15(23):6617-28

PMID:23394829 - Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Gupta S et al. Curr Biol 2013 Feb 18;23(4):333-8

PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Jin QW et al. Genetics 2006 Apr;172(4):2101-12