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protein coding gene - gsf2 (SPCC1742.01) - cell surface glycoprotein, galactose-specific flocculin Gsf2

Gene summary

Standard name
gsf2
Systematic ID
SPCC1742.01
Product
cell surface glycoprotein, galactose-specific flocculin Gsf2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCC1795.13, SPCPB16A4.07c, pfl1
UniProt ID
Q9P6S0
ORFeome ID
50/50A12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 959199..966012 reverse strand

Annotation

Comment

PBO:0114316 - repeat containing

GO biological process

GO:0036349 - galactose-specific flocculation

References:

GO cellular component

GO:0070263 - external side of fungal-type cell wall

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GO:0009897 - external side of plasma membrane

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GO molecular function

GO:0098632 - cell-cell adhesion mediator activity

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Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00728 - galactosylated residue

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MOD:00693 - glycosylated residue

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MOD:00818 - glycosylphosphatidylinositolated residue

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MOD:00006 - N-glycosylated residue

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MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

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MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0000155 - increased flocculation

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000015 - RNA absent

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000010 - abolished cell-substrate adhesion

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Genotypes:

FYPO:0005504 - abolished galactose-specific flocculation

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0000552 - decreased pseudohyphal growth

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Genotypes:

FYPO:0000155 - increased flocculation

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Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Protein features

IDNameInterPro nameDB name
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

References / Literature

PMID:22098069 - Identification of a galactose-specific flocculin essential for non-sexual flocculation and filamentous growth in Schizosaccharomyces pombe.
Matsuzawa T et al. Mol Microbiol 2011 Dec;82(6):1531-44
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23236291 - Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.
Kwon EJ et al. PLoS Genet 2012;8(12):e1003104
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:38482739 - Critical importance of DNA binding for CSL protein functions in fission yeast.
Marešová A et al. J Cell Sci 2024 Mar 14;
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23311928 - The zinc finger protein Gsf1 regulates Gsf2-dependent flocculation in fission yeast.
Matsuzawa T et al. FEMS Yeast Res 2013 May;13(3):259-66
PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
PMID:22180499 - MADS box transcription factor Mbx2/Pvg4 regulates invasive growth and flocculation by inducing gsf2+ expression in fission yeast.
Matsuzawa T et al. Eukaryot Cell 2012 Feb;11(2):151-8
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
GO_REF:0000051 - S. pombe keyword mapping
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7
PMID:26896331 - Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast.
Chatfield-Reed K et al. Genetics 2016 Apr;202(4):1365-75
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14