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protein coding gene - tol1 (SPCC1753.04) - 3'(2'),5'-bisphosphate nucleotidase/inositol-1,4- bisphosphate 1-phosphatase

Gene summary

Standard name
tol1
Systematic ID
SPCC1753.04
Product
3'(2'),5'-bisphosphate nucleotidase/inositol-1,4- bisphosphate 1-phosphatase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94505
ORFeome ID
16/16C08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1549904..1551397 forward strand

Annotation

PBO:0005543 - 3.1.3.57

PBO:0005542 - 3.1.3.7

Comment

PBO:0005541 - target of lithium

Complementation

PBO:0014309 - functionally complemented by S. cerevisiae MET22

References:

Disease association

MONDO:0015020 - intellectual disability, autosomal recessive 59

References:

GO biological process

GO:0180037 - rapid tRNA decay

References:

GO:0000103 - sulfate assimilation

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0008441 - 3'(2'),5'-bisphosphate nucleotidase activity

References:

GO:0052829 - inositol-1,3,4-trisphosphate 1-phosphatase activity

References:

GO:0004441 - inositol-1,4-bisphosphate 1-phosphatase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002583 - decreased mature tRNA level during vegetative growth

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000042 - growth auxotrophic for sulfite

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0002377 - viable swollen vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00459Inositol_PInositol_monophosphatase-likePfam
cd01517PAP_phosphataseCDD
PS00629IMP_1Inositol_monoP_metal-BSPROSITE patterns
PS00630IMP_2Inositol_monophosphatase_CSPROSITE patterns
PR00377IMPHPHTASESInositol_monophosphatase-likePRINTS
G3DSA:3.30.540.10:FF:000015CATH-FunFam
G3DSA:3.40.190.80:FF:000003CATH-FunFam
G3DSA:3.30.540.10CATH-Gene3D
G3DSA:3.40.190.80CATH-Gene3D
SSF56655SUPERFAMILY
PTHR43200Inositol_monoP_superfamilyPANTHER
TIGR01330bisphos_HAL2DPNPNCBIFAM

Orthologs

References / Literature

PMID:10850973 - Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy.
Miyamoto R et al. J Bacteriol 2000 Jul;182(13):3619-25
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:35901126 - Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species.
Tasak M et al. PLoS Genet 2022 Jul;18(7):e1010215
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36