protein coding gene - gms1 (SPCC1795.03) - Golgi UDP-galactose transmembrane transporter Gms1

Gene summary

Standard name

gms1

Systematic ID

SPCC1795.03

Product

Golgi UDP-galactose transmembrane transporter Gms1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

gmn3

UniProt ID

P87041

ORFeome ID

19/19G06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 992878..994986 reverse strand

Annotation

Protein features

Orthologs

• SLC35A2 (HGNC:11022) Homo sapiens
• SLC35A3 (HGNC:11023) Homo sapiens
• gms1 (SJAG_04697) Schizosaccharomyces japonicus
• YPL264C Saccharomyces cerevisiae

References / Literature

PMID:19202278 - The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides.

Ohashi T et al. Biosci Biotechnol Biochem 2009 Feb;73(2):407-14

PMID:27587357 - The conundrum of UDP-Glc entrance into the yeast ER lumen.

Bredeston LM et al. Glycobiology 2017 Jan;27(1):64-79

PMID:10371208 - Schizosaccharomyces pombe UDP-galactose transporter: identification of its functional form through cDNA cloning and expression in mammalian cells.

Segawa H et al. FEBS Lett 1999 May 28;451(3):295-8

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PB_REF:0000003 - Disease Association Curation

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:34389684 - Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.

Schwer B et al. Proc Natl Acad Sci U S A 2021 Aug 17;118(33)

PMID:19844703 - N- and O-linked oligosaccharides completely lack galactose residues in the gms1och1 mutant of Schizosaccharomyces pombe.

Ohashi T et al. Appl Microbiol Biotechnol 2010 Mar;86(1):263-72

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:11447596 - Characterization of a Schizosaccharomyces pombe mutant deficient in UDP-galactose transport activity.

Tanaka N et al. Yeast 2001 Jul;18(10):903-14

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:11693916 - Coflocculation of Escherichia coli and Schizosaccharomyces pombe.

Peng X et al. Appl Microbiol Biotechnol 2001 Oct;57(1-2):175-81

PMID:19942659 - Characterization of two different types of UDP-glucose/-galactose 4-epimerase involved in galactosylation in fission yeast.

Suzuki S et al. Microbiology (Reading) 2010 Mar;156(Pt 3):708-718

PMID:23254763 - Ght2⁺ is required for UDP-galactose synthesis from extracellular galactose by Schizosaccharomyces pombe.

Matsuzawa T et al. Appl Microbiol Biotechnol 2013 Jun;97(11):4957-64

PMID:25378562 - Vsl1p cooperates with Fsv1p for vacuolar protein transport and homotypic fusion in Schizosaccharomyces pombe.

Hosomi A et al. Microbiology (Reading) 2015 Jan;161(Pt 1):89-98

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22098069 - Identification of a galactose-specific flocculin essential for non-sexual flocculation and filamentous growth in Schizosaccharomyces pombe.

Matsuzawa T et al. Mol Microbiol 2011 Dec;82(6):1531-44

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

PMID:11378902 - Functional characterization of Gms1p/UDP-galactose transporter in Schizosaccharomyces pombe.

Tanaka N et al. Yeast 2001 Jun;18(8):745-57

PMID:11472912 - Decrease in cell surface galactose residues of Schizosaccharomyces pombe enhances its coflocculation with Pediococcus damnosus.

Peng X et al. Appl Environ Microbiol 2001 Aug;67(8):3413-7

PMID:22988247 - Identification of novel α1,3-galactosyltransferase and elimination of α-galactose-containing glycans by disruption of multiple α-galactosyltransferase genes in Schizosaccharomyces pombe.

Ohashi T et al. J Biol Chem 2012 Nov 09;287(46):38866-75

PMID:32918581 - Golgi localization of glycosyltransferases requires Gpp74p in Schizosaccharomyces pombe.

Ohashi T et al. Appl Microbiol Biotechnol 2020 Oct;104(20):8897-8909

PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.

Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:21098516 - Structural analysis of α1,3-linked galactose-containing oligosaccharides in Schizosaccharomyces pombe mutants harboring single and multiple α-galactosyltransferase genes disruptions.

Ohashi T et al. Glycobiology 2011 Mar;21(3):340-51

PMID:8782411 - Isolation and characterization of a glycosylation mutant from Schizosaccharomyces pombe.

Takegawa K et al. Biosci Biotechnol Biochem 1996 Jul;60(7):1156-9

PMID:9125114 - The Schizosaccharomyces pombe gms1+ gene encodes an UDP-galactose transporter homologue required for protein galactosylation.

Tabuchi M et al. Biochem Biophys Res Commun 1997 Mar 06;232(1):121-5

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs