protein coding gene - ura6 (SPCC1795.05c) - uridylate kinase Ura6

Gene summary

Standard name: ura6
Systematic ID: SPCC1795.05c
Product: uridylate kinase Ura6
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O59771
ORFeome ID: 06/06B11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 988355..989709 forward strand

Annotation

PBO:0005352 - 2.7.4.-

Disease association

MONDO:0003664 - hemolytic anemia

References:

PB_REF:0000003

GO biological process

GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process

References:

GO_REF:0000024

GO:0046705 - CDP biosynthetic process

References:

GO_REF:0000033

GO:0006225 - UDP biosynthetic process

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0033862 - UMP kinase activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

ura6delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

ura6delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

ura6delta

FYPO:0001357 - normal vegetative cell population growth

References:

PMID:41790722

Genotypes:

FYPO:0002864 - resistance to 5-fluoroorotic acid

References:

PMID:41790722

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

PMID:41790722

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00406	ADK		Pfam
cd01428	ADK	Adenylat/UMP-CMP_kin	CDD
PS00113	ADENYLATE_KINASE	Adenylat_kinase_CS	PROSITE patterns
PR00094	ADENYLTKNASE	Adenylat/UMP-CMP_kin	PRINTS
G3DSA:3.40.50.300:FF:000315			CATH-FunFam
G3DSA:3.40.50.300		P-loop_NTPase	CATH-Gene3D
SSF52540		P-loop_NTPase	SUPERFAMILY
PTHR23359		Adenylat/UMP-CMP_kin	PANTHER
TIGR01359	UMP_CMP_kin_fam	UMP_CMP_kinase	NCBIFAM
MF_00235	Adenylate_kinase_Adk	Adenylat/UMP-CMP_kin	HAMAP
MF_03172	Adenylate_kinase_UMP_CMP_kin	UMP_CMP_kinase	HAMAP

Orthologs

CMPK1 (HGNC:18170) Homo sapiens
ura6 (SJAG_00779) Schizosaccharomyces japonicus
URA6 (YKL024C) Saccharomyces cerevisiae

References / Literature

PB_REF:0000003 - Disease Association Curation
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.: Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000002 - Comments
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:41790722 - Hypomorphic mutations in ura6 confer 5-FOA resistance in fission yeast.: Kowal C et al. PLoS One 2026;21(3):e0344121
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:38479839 - Coordination of histone chaperones for parental histone segregation and epigenetic inheritance.: Fang Y et al. Genes Dev 2024 Mar 13;
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6