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protein coding gene - map2 (SPCC1795.06) - P-factor pheromone Map2

Gene summary

Standard name
map2
Systematic ID
SPCC1795.06
Product
P-factor pheromone Map2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09180
ORFeome ID
06/06G06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 986014..986684 reverse strand

Annotation

Comment

PBO:0011516 - unbinds SPAC11H11.04 with force 120 pN at probe speed 1.74 um/s

References:

GO biological process

GO:0007267 - cell-cell signaling

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GO:0031139 - positive regulation of conjugation with cellular fusion

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GO:0062038 - positive regulation of pheromone response MAPK cascade

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GO cellular component

GO:0009986 - cell surface

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GO:0005576 - extracellular region

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GO molecular function

GO:0000772 - mating pheromone activity

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Modification

MOD:00693 - glycosylated residue

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MOD:01641 - L-leucine removal

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MOD:00006 - N-glycosylated residue

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0100011 - cleaved_peptide_region

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SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000031 - abnormal mating

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0001141 - abolished transcriptional response to pheromone

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Genotypes:

FYPO:0004075 - decreased cell growth

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0000333 - mitotic G1/S phase transition delay

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Genotypes:

FYPO:0001046 - premature mitosis

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Orthologs

References / Literature

PMID:10792724 - Sxa2 is a serine carboxypeptidase that degrades extracellular P-factor in the fission yeast Schizosaccharomyces pombe.
Ladds G et al. Mol Microbiol 2000 Apr;36(2):377-90
PMID:12501333 - Induction of sexual co-flocculation of heterothallic fission yeast (Schizosaccharomyces pombe) cells by mating pheromones.
Miyata M et al. J Gen Appl Microbiol 1997 Jun;43(3):169-174
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.
Stern B et al. EMBO J 1997 Feb 03;16(3):534-44
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.
Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:8879048 - Purification of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.
Ladds G et al. Biochem Soc Trans 1996 Aug;24(3):504S
PMID:22500108 - Interaction between pheromone and its receptor of the fission yeast Schizosaccharomyces pombe examined by a force spectroscopy study.
Sasuga S et al. J Biomed Biotechnol 2012;2012:804793
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:12172965 - Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.
Didmon M et al. Curr Genet 2002 Jul;41(4):241-53
PMID:8736868 - Characterisation of Sxa2, a carboxypeptidase involved in pheromone recovery in fission yeast.
Ladds G et al. Biochem Soc Trans 1996 May;24(2):210S
PMID:8654750 - Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.
Ladds G et al. Biochem Soc Trans 1995 Nov;23(4):565S
PMID:8314086 - The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.
Imai Y et al. Genes Dev 1994 Feb 01;8(3):328-38
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:8861202 - The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe.
Ladds G et al. Mol Microbiol 1996 Apr;20(1):35-42
PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:4716873 - Genes involved in mating type expression of fission yeast.
Egel R Mol Gen Genet 1973 May 28;122(4):339-43
PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:9191272 - Sxa2, a carboxypeptidase that degrades extracellular pheromone in fission yeast.
Ladds G et al. Biochem Soc Trans 1997 May;25(2):228S
PMID:7813430 - Isolation and characterization of krp, a dibasic endopeptidase required for cell viability in the fission yeast Schizosaccharomyces pombe.
Davey J et al. EMBO J 1994 Dec 15;13(24):5910-21
PMID:1657593 - The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein.
Kitamura K et al. EMBO J 1991 Dec;10(12):3743-51
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008