protein coding gene - utp23 (SPCC18.12c) - rRNA processing protein Utp23

Gene summary

Standard name: utp23
Systematic ID: SPCC18.12c
Product: rRNA processing protein Utp23
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O74862
ORFeome ID: 16/16G01
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 1977107..1978532 reverse strand

Annotation

GO biological process

GO:0006364 - rRNA processing

References:

GO_REF:0000024

GO cellular component

GO:0005730 - nucleolus

References:

PMID:16823372

GO:0032040 - small-subunit processome

References:

GO_REF:0000033

GO molecular function

GO:0004540 - RNA nuclease activity

References:

GO_REF:0000117

GO:0070181 - small ribosomal subunit rRNA binding

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

MOD:00047 - O-phospho-L-threonine

References:

PMID:25720772

MOD:01149 - sumoylated lysine

References:

PMID:26537787

Protein features

PBO:0111881 - PINc domain

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

utp23delta

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

PMID:23697806

Genotypes:

utp23delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

utp23delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

utp23delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF04900	Fcf1	Fcf1/UTP23	PFAM
PF24779	UTP23_sensor	UTP23_sensor	PFAM
cd09865	PIN_ScUtp23p-like		CDD
SM00670	PIN_9	PIN_dom	SMART
G3DSA:3.40.50.1010:FF:000006			FUNFAM
SSF88723	PIN domain-like	PIN-like_dom_sf	SUPERFAMILY
G3DSA:3.40.50.1010			GENE3D
PTHR12416	RRNA-PROCESSING PROTEIN UTP23 HOMOLOG		PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder

Orthologs

UTP23 (HGNC:28224) Homo sapiens
utp23 (SJAG_00253) Schizosaccharomyces japonicus
UTP23 (YOR004W) Saccharomyces cerevisiae

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.: Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.: Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.: Zhang K et al. Science 2011 Mar 25;331(6024):1624-7
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053