protein coding gene - fum1 (SPCC18.18c) - fumarate hydratase Fum1

Gene summary

Standard name: fum1
Systematic ID: SPCC18.18c
Product: fumarate hydratase Fum1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPCC290.01c
UniProt ID: O94552
ORFeome ID: 23/23D04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome III: 1988324..1990734 reverse strand

Annotation

PBO:0005721 - 4.2.1.2

Disease association

MONDO:0011730 - fumaric aciduria

References:

PB_REF:0000006

MONDO:0007888 - hereditary leiomyomatosis and renal cell cancer

References:

PB_REF:0000006

GO biological process

GO:0006302 - double-strand break repair

References:

GO_REF:0000024

GO:0006106 - fumarate metabolic process

References:

GO_REF:0000033

GO:0006108 - malate metabolic process

References:

GO_REF:0000033

GO:0006099 - tricarboxylic acid cycle

References:

PMID:37164017

GO cellular component

GO:0005829 - cytosol

References:

GO_REF:0000024

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO:0005634 - nucleus

References:

GO_REF:0000024

GO molecular function

GO:0004333 - fumarate hydratase activity

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39705284

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00206	Lyase_1	Fumarate_lyase_N	PFAM
PF10415	FumaraseC_C	Fumarase_C_C	PFAM
cd01362	Fumarase_classII	Fum_hydII	CDD
PS00163	FUMARATE_LYASES	Fumarate_lyase_CS	PROSITE_PATTERNS
PR00149	FUMRATELYASE	Fumarate_lyase_fam	PRINTS
G3DSA:1.20.200.10:FF:000001			FUNFAM
G3DSA:1.10.275.10:FF:000001			FUNFAM
G3DSA:1.10.40.30:FF:000002			FUNFAM
SSF48557	L-aspartase-like	L-Aspartase-like	SUPERFAMILY
G3DSA:1.10.275.10		Fumarase/histidase_N	GENE3D
G3DSA:1.10.40.30			GENE3D
G3DSA:1.20.200.10	Fumarase/aspartase (Central domain)		GENE3D
PTHR11444	ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE	Fum_hydII	PANTHER
MF_00743	FumaraseC	Fum_hydII	HAMAP
TIGR00979	fumC_II	Fum_hydII	NCBIFAM
NF008909	PRK12273.1		NCBIFAM

Orthologs

FH (HGNC:3700) Homo sapiens
fum1 (SJAG_04843) Schizosaccharomyces japonicus
FUM1 (YPL262W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.: Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.: Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:37164017 - Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.: Alam S et al. Curr Biol 2023 Jun 05;33(11):2175-2186.e5