protein coding gene - pca1 (SPCC1840.04) - metacaspase Pca1

Gene summary

Standard name

pca1

Systematic ID

SPCC1840.04

Product

metacaspase Pca1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74477

ORFeome ID

24/24A08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 2263967..2267305 forward strand

Annotation

Protein features

Orthologs

• pca1 (SJAG_00135) Schizosaccharomyces japonicus
• MCA1 (YOR197W) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19606215 - Calnexin regulates apoptosis induced by inositol starvation in fission yeast.

Guérin R et al. PLoS One 2009 Jul 16;4(7):e6244

PMID:21670521 - Apoptotic cell death in the fission yeast Schizosaccharomyces pombe induced by valproic acid and its extreme susceptibility to pH change.

Mutoh N et al. Biosci Biotechnol Biochem 2011;75(6):1113-8

PMID:12597774 - Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation.

Ho JC et al. Biochem J 2003 May 15;372(Pt 1):97-104

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14

PMID:17898859 - Overexpression of a metacaspase gene stimulates cell growth and stress response in Schizosaccharomyces pombe.

Lim HW et al. Can J Microbiol 2007 Aug;53(8):1016-23

PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.

Idiris A et al. Yeast 2006 Jan 30;23(2):83-99

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:32347926 - Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe).

Agus HH et al. FEMS Yeast Res 2020 Jun 01;20(4)

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:18653539 - Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast.

Low CP et al. J Cell Sci 2008 Aug 15;121(Pt 16):2671-84

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.