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protein coding gene - lsm8 (SPCC1840.10) - Lsm2-8 complex subunit Lsm8

Gene summary

Standard name
lsm8
Systematic ID
SPCC1840.10
Product
Lsm2-8 complex subunit Lsm8
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74483
ORFeome ID
03/03B02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 2277878..2278303 forward strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO:1905323 - telomerase holoenzyme complex assembly

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0120115 - Lsm2-8 complex

References:

GO:0005634 - nucleus

References:

GO:0071011 - precatalytic spliceosome

References:

GO:0005697 - telomerase holoenzyme complex

References:

GO:0005686 - U2 snRNP

References:

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO:0005682 - U5 snRNP

References:

GO:0005688 - U6 snRNP

References:

GO molecular function

GO:0003729 - mRNA binding

References:

GO:0005515 - protein binding

References:

GO:0140691 - RNA folding chaperone

References:

GO:0030620 - U2 snRNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009060 - resistance to wortmannin

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01423LSMSm_dom_euk/arcPFAM
cd01727LSm8Lsm8CDD
PS52002SMSmPROSITE_PROFILES
SM00651Sm3Sm_dom_euk/arcSMART
G3DSA:2.30.30.100:FF:000027FUNFAM
SSF50182Sm-like ribonucleoproteinsLSM_dom_sfSUPERFAMILY
G3DSA:2.30.30.100GENE3D
PTHR15588LSM1PTHR15588PANTHER

Orthologs

References / Literature

PMID:26292707 - Structure of a yeast spliceosome at 3.6-angstrom resolution.
Yan C et al. Science 2015 Sep 11;349(6253):1182-91
PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.
Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24
PMID:21572561 - 3' processing of eukaryotic precursor tRNAs.
Maraia RJ et al. Wiley Interdiscip Rev RNA 2011;2(3):362-75
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.
Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22001694 - Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings.
Mund M et al. J Mol Biol 2011 Nov 25;414(2):165-76
PMID:31657618 - A Genome-Wide Screen for Wortmannin-Resistant Mutants in Schizosaccharomyces pombe: The Phosphorylation-Impaired Mutants Are Resistant to Signaling Defect.
Yılmazer M et al. DNA Cell Biol 2019 Dec;38(12):1427-1436
PMID:33378677 - Quality-Control Mechanism for Telomerase RNA Folding in the Cell.
Hu X et al. Cell Rep 2020 Dec 29;33(13):108568
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:32518066 - Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes.
Montemayor EJ et al. RNA 2020 Oct;26(10):1400-1413
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
Porat J et al. Nat Commun 2022 Mar 11;13(1):1277
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22446625 - Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes.
Tang W et al. Nature 2012 Mar 25;484(7393):260-4
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83