PomBase home

protein coding gene - par1 (SPCC188.02) - serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1

Gene summary

Standard name
par1
Systematic ID
SPCC188.02
Product
serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pbp1
UniProt ID
Q10428
ORFeome ID
51/51E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1475573..1478103 forward strand

Annotation

Complementation

PBO:0120680 - functionally complemented by human PPP2R5D

References:

PBO:0017584 - functionally complements S. cerevisiae RTS1

References:

Disease association

MONDO:0014602 - Houge-Janssens syndrome 1

References:

MONDO:0978293 - Houge-Janssens syndrome 4

References:

GO biological process

GO:1902426 - deactivation of mitotic spindle assembly checkpoint

References:

GO:1990813 - meiotic centromeric cohesion protection in anaphase I

References:

GO:0031568 - mitotic G1 cell size control checkpoint signaling

References:

GO:0031030 - negative regulation of septation initiation signaling

References:

GO:0007089 - traversing start control point of mitotic cell cycle

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0000775 - chromosome, centromeric region

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0000939 - inner kinetochore

References:

GO:0072687 - meiotic spindle

References:

GO:0110085 - mitotic actomyosin contractile ring

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0000159 - protein phosphatase type 2A complex

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0072542 - protein phosphatase activator activity

References:

GO:0030674 - protein-macromolecule adaptor activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0007476 - decreased duration of cell cycle arrest in mitotic G1 phase

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0002798 - decreased protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0001283 - decreased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0006559 - delayed onset of mitotic spindle disassembly

References:

Genotypes:

FYPO:0000998 - elongated cell during nitrogen starvation

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0007758 - increased duration of mitotic sister chromatid cohesion

References:

Genotypes:

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0001043 - increased mating efficiency

References:

Genotypes:

FYPO:0002277 - increased protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0003536 - increased septation index in stationary phase

References:

Genotypes:

FYPO:0002024 - inviable elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0003903 - loss of viability at low temperature

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0001254 - multinucleate multiseptate vegetative cell, septa grouped

References:

Genotypes:

FYPO:0004297 - multiseptate cell in stationary phase

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0001000 - normal cell cycle arrest in mitotic G1 phase during nitrogen starvation

References:

Genotypes:

FYPO:0001022 - normal growth during cellular response to high osmolarity

References:

Genotypes:

FYPO:0002801 - normal protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0005709 - normal protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0002873 - normal septum orientation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0003302 - nucleus mislocalized towards cell tip during mitotic interphase

References:

Genotypes:

FYPO:0001966 - sensitive to aculeacin A

References:

Genotypes:

FYPO:0000094 - sensitive to benomyl

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000105 - sensitive to cyclosporin A

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0000112 - sensitive to sorbitol

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002342 - septated vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000020 - protein level unchanged

References:

PomGeneEx:0000021 - protein present

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000031 - abnormal mating

References:

Genotypes:

FYPO:0000117 - abnormal septum assembly

References:

Genotypes:

FYPO:0003345 - abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0004763 - abolished protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0006825 - abolished protein localization to mitotic spindle pole body during mitosis

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001054 - cut, elongated cell

References:

Genotypes:

FYPO:0001876 - decreased asymmetric protein localization, with protein localized to both mitotic spindle pole bodies during anaphase

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0000460 - decreased mitotic centromeric sister chromatid cohesion

References:

Genotypes:

FYPO:0002798 - decreased protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0005034 - decreased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002049 - elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0009011 - increased cell population viability on galactose carbon source

References:

Genotypes:

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0002277 - increased protein degradation during nitrogen starvation

References:

Genotypes:

FYPO:0001758 - increased protein phosphatase activity

References:

Genotypes:

FYPO:0007897 - increased protein phosphorylation during mitotic exit

References:

Genotypes:

FYPO:0002681 - increased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0000650 - increased septation index

References:

Genotypes:

FYPO:0003536 - increased septation index in stationary phase

References:

Genotypes:

FYPO:0001406 - increased septum thickness

References:

Genotypes:

FYPO:0009008 - increased vegetative cell population viability

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0004163 - increased viability upon glucose starvation

References:

Genotypes:

FYPO:0000238 - inviable cell upon G0 to G1 transition

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0003903 - loss of viability at low temperature

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0006660 - loss of viability upon G0 to G1 transition

References:

Genotypes:

FYPO:0002071 - mislocalized nucleus during vegetative growth

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0004294 - mislocalized septum in stationary phase

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0004297 - multiseptate cell in stationary phase

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002219 - normal chromosome disjunction at meiosis I

References:

Genotypes:

FYPO:0001037 - normal growth during cellular response to salt stress

References:

Genotypes:

FYPO:0000961 - normal growth on sorbitol

References:

Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0003176 - normal meiotic chromosome segregation

References:

Genotypes:

FYPO:0004084 - normal protein level during nitrogen starvation

References:

Genotypes:

FYPO:0004214 - normal protein localization to kinetochore during meiosis I

References:

Genotypes:

FYPO:0007661 - normal protein localization to kinetochore during meiotic metaphase I

References:

Genotypes:

FYPO:0005035 - normal protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001120 - pear-shaped vegetative cell

References:

Genotypes:

FYPO:0000441 - resistance to antimycin A

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0003824 - resistance to caffeine and rapamycin

References:

Genotypes:

FYPO:0001029 - resistance to canavanine

References:

Genotypes:

FYPO:0002634 - resistance to cobalt

References:

Genotypes:

FYPO:0009047 - resistance to dimethyl sulfoxide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

References:

Genotypes:

FYPO:0009037 - resistance to phloxine B

References:

Genotypes:

FYPO:0009046 - resistance to phloxine B and hydrogen peroxide

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0005266 - resistance to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009042 - resistance to sorbitol

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0001966 - sensitive to aculeacin A

References:

Genotypes:

FYPO:0000094 - sensitive to benomyl

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0007926 - sensitive to calcofluor and potassium chloride

References:

Genotypes:

FYPO:0000105 - sensitive to cyclosporin A

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0007932 - sensitive to hydroxyurea and methyl methanesulfonate

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0007925 - sensitive to sodium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0000086 - sensitive to tacrolimus

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

References:

Genotypes:

FYPO:0003182 - sister chromatid nondisjunction at meiosis II

References:

Genotypes:

FYPO:0005648 - sister kinetochore dissociation in meiotic metaphase I

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01603B56PP2A_B56Pfam
G3DSA:1.25.10.10:FF:000016CATH-FunFam
G3DSA:1.25.10.10ARM-likeCATH-Gene3D
SSF48371ARM-type_foldSUPERFAMILY
PTHR10257PP2A_B56PANTHER
PIRSF028043PP2A_B56PP2A_B56PIRSF
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.
Stonyte V et al. iScience 2020 May 22;23(5):101063
PMID:12546793 - Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.
Krapp A et al. Curr Biol 2003 Jan 21;13(2):168-72
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:22403715 - Regulation of fission yeast morphogenesis by PP2A activator pta2.
Bernal M et al. PLoS One 2012;7(3):e32823
PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11380623 - Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin.
Tanabe O et al. Genes Cells 2001 May;6(5):455-73
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.
Bernal M et al. Proteomics 2014 Jun;14(11):1367-80
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
PMID:16541025 - Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
Kitajima TS et al. Nature 2006 May 04;441(7089):46-52
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:25487150 - A PP1-PP2A phosphatase relay controls mitotic progression.
Grallert A et al. Nature 2015 Jan 01;517(7532):94-98
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:41786187 - Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.
Zhang K et al. Int J Biol Macromol 2026 Mar 03;:151175
PMID:10757751 - Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2A.
Jiang W et al. Genetics 2000 Mar;154(3):1025-38
PMID:11707284 - The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.
Le Goff X et al. FEBS Lett 2001 Nov 09;508(1):136-42
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.
Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619
PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6
PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.
Ma W et al. Genes Dev 2021 May 01;35(9-10):692-697
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:20739936 - Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Tsukahara T et al. Nature 2010 Oct 07;467(7316):719-23
PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.
Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.
Ma Y et al. PLoS One 2011;6(8):e23422
PMID:11514436 - Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.
Jiang W et al. Genetics 2001 Aug;158(4):1413-29
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.
Goyal A et al. Genetics 2012 Apr;190(4):1235-50
PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Mojardín L et al. Cell Cycle 2015;14(2):206-18
PMID:30116786 - Genetic regulation of mitotic competence in G 0 quiescent cells.
Sajiki K et al. Sci Adv 2018 Aug;4(8):eaat5685
PMID:19597328 - Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.
Cadou A et al. Cell Cycle 2009 Aug;8(15):2451-62
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.
Jin QW et al. Genetics 2006 Apr;172(4):2101-12
PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.
Deng DJ et al. FASEB J 2022 Sep;36(9):e22524
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:18716626 - Heterochromatin links to centromeric protection by recruiting shugoshin.
Yamagishi Y et al. Nature 2008 Sep 11;455(7210):251-5
PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG et al. Nature 2006 May 04;441(7089):53-61
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963