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protein coding gene - cnd3 (SPCC188.03) - condensin complex non-SMC subunit Cnd3

Gene summary

Standard name
cnd3
Systematic ID
SPCC188.03
Product
condensin complex non-SMC subunit Cnd3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10429
ORFeome ID
51/51E11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1478203..1481959 forward strand

Annotation

GO biological process

GO:0007076 - mitotic chromosome condensation

References:

GO cellular component

GO:0000793 - condensed chromosome

References:

GO:0000796 - condensin complex

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GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0061776 - ATP-dependent topological DNA co-entrapment activity

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GO:0106260 - DNA-DNA tethering activity

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GO:1990814 - DNA/DNA annealing activity

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GO:0003690 - double-stranded DNA binding

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GO:0005515 - protein binding

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GO:0003697 - single-stranded DNA binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01149 - sumoylated lysine

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein features

PBO:0111765 - HEAT repeat

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000214 - abnormal mitotic chromosome condensation

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Genotypes:

FYPO:0006302 - abolished intra-arm chromosome contact change during mitosis

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Genotypes:

FYPO:0005934 - abolished protein sumoylation during vegetative growth

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Genotypes:

FYPO:0003286 - decreased mitotic chromosome condensation

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Genotypes:

FYPO:0001382 - decreased protein kinase activity

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Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

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Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006887 - normal protein sumoylation during vegetative growth

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0002546 - sensitive to trichostatin A

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Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12719Cnd3Cnd3_CPFAM
SSF48371ARM repeatARM-type_foldSUPERFAMILY
G3DSA:1.25.10.10ARM-likeGENE3D
PTHR14418CONDENSIN COMPLEX SUBUNIT 3-RELATEDCND3PANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.
Xu X et al. PLoS One 2015;10(3):e0119347
PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.
Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98
PMID:28825727 - Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.
Kakui Y et al. Nat Genet 2017 Oct;49(10):1553-1557
PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.
Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807
PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.
Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.
Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81
PMID:25520186 - ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.
Akai Y et al. Open Biol 2014 Dec;4(12)
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.
Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.
Aono N et al. Nature 2002 May 09;417(6885):197-202
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28988770 - Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.
Kschonsak M et al. Cell 2017 Oct 19;171(3):588-600.e24
PMID:37820734 - Establishment of dsDNA-dsDNA interactions by the condensin complex.
Tang M et al. Mol Cell 2023 Nov 02;83(21):3787-3800.e9
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:10485849 - Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.
Sutani T et al. Genes Dev 1999 Sep 01;13(17):2271-83
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.
Akai Y et al. Open Biol 2011 Dec;1(4):110023
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36