protein coding gene - dcr1 (SPCC188.13c) - dicer

Gene summary

Standard name

dcr1

Systematic ID

SPCC188.13c

Product

dicer

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPCC584.10c

UniProt ID

Q09884

ORFeome ID

30/30F09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1504949..1510557 reverse strand

Annotation

Protein features

Orthologs

• DICER1 (HGNC:17098) Homo sapiens
• dcr1 (SJAG_03689) Schizosaccharomyces japonicus

References / Literature

PMID:15615848 - RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.

Sugiyama T et al. Proc Natl Acad Sci U S A 2005 Jan 04;102(1):152-7

PMID:23478021 - Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.

Li PC et al. Cell Rep 2013 Mar 28;3(3):638-45

PMID:20705239 - The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation.

Gerace EL et al. Mol Cell 2010 Aug 13;39(3):360-72

PMID:32496538 - Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.

Sansó M et al. Nucleic Acids Res 2020 Jul 27;48(13):7154-7168

PMID:31822915 - Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast.

Taglini F et al. Nucleic Acids Res 2020 Feb 20;48(3):1239-1253

PMID:20178743 - Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.

Halic M et al. Cell 2010 Feb 19;140(4):504-16

PMID:25774602 - Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.

Wang J et al. Elife 2015 Mar 16;4

PMID:27343236 - Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.

Murton HE et al. Genetics 2016 Aug;203(4):1669-78

PMID:38289024 - Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.

Sun L et al. Elife 2024 Jan 30;13

PMID:25831549 - Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.

Ragunathan K et al. Science 2015 Apr 03;348(6230):1258699

PMID:23151475 - RNAi triggered by specialized machinery silences developmental genes and retrotransposons.

Yamanaka S et al. Nature 2013 Jan 24;493(7433):557-60

PMID:19164572 - Msc1 links dynamic Swi6/HP1 binding to cell fate determination.

Lawrence RJ et al. Proc Natl Acad Sci U S A 2009 Jan 27;106(4):1163-8

PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.

Larkin A et al. Dev Cell 2024 Jul 26;

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:29654060 - RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.

Begnis M et al. Genes Dev 2018 Apr 01;32(7-8):537-554

PMID:22431512 - RNAi keeps Atf1-bound stress response genes in check at nuclear pores.

Woolcock KJ et al. Genes Dev 2012 Apr 01;26(7):683-92

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:20421495 - RNAi and heterochromatin repress centromeric meiotic recombination.

Ellermeier C et al. Proc Natl Acad Sci U S A 2010 May 11;107(19):8701-5

PMID:22002604 - RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.

Zaratiegui M et al. Nature 2011 Oct 16;479(7371):135-8

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25417108 - Dicer promotes transcription termination at sites of replication stress to maintain genome stability.

Castel SE et al. Cell 2014 Oct 23;159(3):572-83

PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641

PMID:22989756 - RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.

Iida T et al. Biochem Biophys Res Commun 2012 Oct 12;427(1):143-7

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:27538348 - Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast.

Yu Y et al. Sci Rep 2016 Aug 19;6:31752

PMID:29722648 - Distinct 'safe zones' at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.

Ebrahimi H et al. Elife 2018 May 03;7

PMID:24095277 - Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.

Marasovic M et al. Mol Cell 2013 Oct 24;52(2):173-83

PMID:26205977 - Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.

Matsuda A et al. Nat Commun 2015 Jul 24;6:7753

PMID:27334362 - Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions.

Tange Y et al. Genes Cells 2016 Aug;21(8):812-32

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:12193640 - Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.

Volpe TA et al. Science 2002 Sep 13;297(5588):1833-7

PMID:16734665 - RNA interference effector proteins localize to mobile cytoplasmic puncta in Schizosaccharomyces pombe.

Carmichael JB et al. Traffic 2006 Aug;7(8):1032-44

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.

Seo HD et al. Curr Genet 2018 Jun;64(3):741-752

PMID:18345014 - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

Zhang K et al. Nat Struct Mol Biol 2008 Apr;15(4):381-8

PMID:24013500 - A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism.

Marina DB et al. Genes Dev 2013 Sep 01;27(17):1851-6

PMID:15218150 - RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.

Jia S et al. Science 2004 Jun 25;304(5679):1971-6

PMID:22268381 - The karyopherin Sal3 is required for nuclear import of the core RNA interference pathway protein Rdp1.

Park J et al. Traffic 2012 Apr;13(4):520-31

PMID:12482946 - Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

Provost P et al. Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16648-53

PMID:14699070 - ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe.

Carmichael JB et al. Mol Biol Cell 2004 Mar;15(3):1425-35

PMID:28199302 - Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.

Folco HD et al. Nature 2017 Mar 02;543(7643):126-130

PMID:39786922 - The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery.

Chakraborty S et al. Biol Open 2024 Dec 15;13(12)

PMID:28648780 - The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

Flury V et al. Mol Cell 2017 Jul 20;67(2):294-307.e9

PMID:14704433 - RNAi-mediated targeting of heterochromatin by the RITS complex.

Verdel A et al. Science 2004 Jan 30;303(5658):672-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:15372076 - A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.

Sadaie M et al. EMBO J 2004 Oct 01;23(19):3825-35

PMID:22733737 - Ers1 links HP1 to RNAi.

Rougemaille M et al. Proc Natl Acad Sci U S A 2012 Jul 10;109(28):11258-63

PMID:33511417 - Repression of a large number of genes requires interplay between homologous recombination and HIRA.

Misova I et al. Nucleic Acids Res 2021 Feb 26;49(4):1914-1934

PMID:24493644 - lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Shah S et al. Genes Dev 2014 Feb 01;28(3):231-44

GO_REF:0000002 - Comments

PMID:20211136 - Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

Bayne EH et al. Cell 2010 Mar 05;140(5):666-77

PMID:38048463 - Rex1BD and the 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC.

Gao J et al. Proc Natl Acad Sci U S A 2023 Dec 12;120(50):e2309359120

PMID:26443059 - Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.

Deng X et al. Sci Rep 2015 Oct 07;5:14707

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21892171 - Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE et al. Nat Struct Mol Biol 2011 Sep 04;18(10):1132-8

PMID:16797182 - Conserved ribonuclease, Eri1, negatively regulates heterochromatin assembly in fission yeast.

Iida T et al. Curr Biol 2006 Jul 25;16(14):1459-64

PMID:27738016 - RNA interference is essential for cellular quiescence.

Roche B et al. Science 2016 Nov 11;354(6313)

PMID:17948055 - The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.

Trewick SC et al. EMBO J 2007 Nov 14;26(22):4670-82

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:24462781 - RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe.

Smialowska A et al. Biochem Biophys Res Commun 2014 Feb 07;444(2):254-9

PMID:18948543 - Splicing factors facilitate RNAi-directed silencing in fission yeast.

Bayne EH et al. Science 2008 Oct 24;322(5901):602-6

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:21151114 - Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe.

Woolcock KJ et al. Nat Struct Mol Biol 2011 Jan;18(1):94-9

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:28541282 - Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.

Pisacane P et al. Nat Commun 2017 May 25;8:15332

PMID:23966866 - Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways.

Oya E et al. PLoS Genet 2013;9(8):e1003677

PMID:15947136 - RNA polymerase II is required for RNAi-dependent heterochromatin assembly.

Kato H et al. Science 2005 Jul 15;309(5733):467-9

PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.

Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:33378674 - The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin.

Shan CM et al. Cell Rep 2020 Dec 29;33(13):108561

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:35908934 - Euchromatin factors HULC and Set1C affect heterochromatin organization and mating-type switching in fission yeast Schizosaccharomyces pombe.

Esquivel-Chávez A et al. Genes Genet Syst 2022 Oct 18;97(3):123-138

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:20018856 - Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.

Chinen M et al. J Biol Chem 2010 Feb 19;285(8):5630-8

PMID:20062003 - Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.

Simmer F et al. EMBO Rep 2010 Feb;11(2):112-8

PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.

Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:19883398 - The Kinesin motor protein Cut7 regulates biogenesis and function of Ago1-complexes.

Stoica C et al. Traffic 2010 Jan;11(1):25-36

PMID:15475954 - RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing.

Noma K et al. Nat Genet 2004 Nov;36(11):1174-80

PMID:21847092 - An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer.

Barraud P et al. EMBO J 2011 Aug 16;30(20):4223-35

PMID:32499408 - The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast.

Sun L et al. J Cell Sci 2020 Jul 07;133(13)

PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH et al. Genome Biol 2014;15(10):481

PMID:21253571 - H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.

Hansen KR et al. PLoS Genet 2011 Jan 06;7(1):e1001268

PMID:22895252 - A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA.

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PMID:34010645 - The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.

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PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:29975684 - Bases of antisense lncRNA-associated regulation of gene expression in fission yeast.

Wery M et al. PLoS Genet 2018 Jul;14(7):e1007465

PMID:17981703 - Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe.

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PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

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PMID:25543137 - Dicer and Hsp104 function in a negative feedback loop to confer robustness to environmental stress.

Oberti D et al. Cell Rep 2015 Jan 06;10(1):47-61

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:22474355 - Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.

Hayashi A et al. Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6159-64

PMID:16246721 - The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast.

Yamada T et al. Mol Cell 2005 Oct 28;20(2):173-85

PMID:21725325 - Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.

Li F et al. Nature 2011 Jul 03;475(7355):244-8

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:17380189 - Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function.

Murakami H et al. PLoS One 2007 Mar 21;2(3):e317

PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.

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PMID:21289066 - Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions.

Reddy BD et al. Genes Dev 2011 Feb 01;25(3):214-9

PMID:41316862 - Deletion of Elongator Protein 1 (Elp1) relieves heterochromatin defects in a Pol II mutant of Schizosaccharomyces pombe.

Nirmal MB et al. Genetics 2025 Nov 29;

PMID:40063661 - Fission yeast Caprin protein is required for efficient heterochromatin establishment.

Zhang H et al. PLoS Genet 2025 Mar 10;21(3):e1011620

PMID:23572080 - Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance.

Buscaino A et al. EMBO J 2013 May 02;32(9):1250-64

PMID:35194019 - Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4.

Gutbrod MJ et al. Nat Commun 2022 Feb 22;13(1):1001

PMID:25428589 - Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast.

Ard R et al. Nat Commun 2014 Nov 27;5:5576

PMID:38479839 - Coordination of histone chaperones for parental histone segregation and epigenetic inheritance.

Fang Y et al. Genes Dev 2024 Mar 13;

PMID:23771057 - Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

Alper BJ et al. EMBO J 2013 Aug 28;32(17):2321-35

PMID:30652128 - Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription.

Okita AK et al. Commun Biol 2019;2:17

PMID:15907173 - Expression and purification of the carboxyl terminus domain of Schizosaccharomyces pombe dicer in Escherichia coli.

Qian Z et al. Protein Pept Lett 2005 May;12(4):311-4

PMID:15632061 - Global effects on gene expression in fission yeast by silencing and RNA interference machineries.

Hansen KR et al. Mol Cell Biol 2005 Jan;25(2):590-601

PMID:16407326 - Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1.

Hansen KR et al. Nucleic Acids Res 2006;34(1):78-88

PMID:15908586 - The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres.

Walfridsson J et al. Nucleic Acids Res 2005;33(9):2868-79

PMID:19136623 - Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.

Shimada A et al. Genes Dev 2009 Jan 01;23(1):18-23

PMID:28231281 - The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin.

Mutazono M et al. PLoS Genet 2017 Feb;13(2):e1006606

PMID:29237752 - Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.

Kajitani T et al. Proc Natl Acad Sci U S A 2017 Dec 26;114(52):E11208-E11217

PMID:30089114 - Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.

Yang J et al. PLoS Genet 2018 Aug;14(8):e1007572

PMID:26889830 - A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.

Tucker JF et al. PLoS Genet 2016 Feb;12(2):e1005873

PMID:22144463 - RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.

Zofall M et al. Science 2012 Jan 06;335(6064):96-100

PMID:22683269 - HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.

Keller C et al. Mol Cell 2012 Jul 27;47(2):215-27

PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.

Bühler M et al. Cell 2007 May 18;129(4):707-21

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:15607976 - Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.

Motamedi MR et al. Cell 2004 Dec 17;119(6):789-802

PMID:22522705 - Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast.

Hiriart E et al. EMBO J 2012 May 16;31(10):2296-308

PMID:22319459 - Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

Buscaino A et al. PLoS Genet 2012 Feb;8(2):e1002499

PMID:15743828 - RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.

Petrie VJ et al. Mol Cell Biol 2005 Mar;25(6):2331-46

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8