protein coding gene - wee1 (SPCC18B5.03) - M phase inhibitor protein kinase Wee1

Gene summary

Standard name

wee1

Systematic ID

SPCC18B5.03

Product

M phase inhibitor protein kinase Wee1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P07527

ORFeome ID

47/47A06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 721804..725835 forward strand

Annotation

Protein features

Orthologs

• WEE1 (HGNC:12761) Homo sapiens
• WEE2 (HGNC:19684) Homo sapiens
• PKMYT1 (HGNC:29650) Homo sapiens
• wee1 (SJAG_04280) Schizosaccharomyces japonicus
• SWE1 (YJL187C) Saccharomyces cerevisiae

References / Literature

PMID:11715017 - Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

Tanaka K et al. Nat Cell Biol 2001 Nov;3(11):966-72

PMID:26071525 - Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.

Guzmán-Vendrell M et al. J Cell Sci 2015 Aug 01;128(15):2842-53

PMID:10637286 - Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint.

Baber-Furnari BA et al. Mol Biol Cell 2000 Jan;11(1):1-11

PMID:20679488 - Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Sanders SL et al. Mol Cell Biol 2010 Oct;30(19):4722-31

PMID:28924043 - Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.

Opalko HE et al. J Biol Chem 2017 Nov 10;292(45):18457-18468

PMID:7768995 - The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis.

al-Khodairy F et al. J Cell Sci 1995 Feb;108 ( Pt 2):475-86

PMID:10233158 - Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Rupes I et al. Mol Biol Cell 1999 May;10(5):1495-510

PMID:26869222 - Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

Takemoto A et al. J Cell Sci 2016 Mar 15;129(6):1250-9

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:872891 - Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division.

Fantes P et al. Exp Cell Res 1977 Jul;107(2):377-86

PMID:9188094 - Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade.

Shiozaki K et al. Mol Biol Cell 1997 Mar;8(3):409-19

PMID:21233285 - Spatiotemporal regulations of Wee1 at the G2/M transition.

Masuda H et al. Mol Biol Cell 2011 Mar 01;22(5):555-69

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8045419 - Identification of a Xenopus cDNA that prevents mitotic catastrophe in the fission yeast Schizosaccharomyces pombe.

Su JY et al. Gene 1994 Jul 22;145(1):155-6

PMID:19357077 - Autoinhibition and autoactivation of the DNA replication checkpoint kinase Cds1.

Xu YJ et al. J Biol Chem 2009 Jun 05;284(23):16016-27

PMID:7808417 - A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe.

Warbrick E et al. Mol Gen Genet 1994 Dec 01;245(5):654-7

PMID:24006256 - Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.

Yu ZY et al. J Cell Sci 2013 Nov 01;126(Pt 21):4995-5004

PMID:1706223 - mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.

Lundgren K et al. Cell 1991 Mar 22;64(6):1111-22

PMID:1316996 - Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.

Ayscough K et al. Mol Gen Genet 1992 Apr;232(3):344-50

PMID:15297457 - On the slowing of S phase in response to DNA damage in fission yeast.

Kumar S et al. J Biol Chem 2004 Oct 15;279(42):43574-80

PMID:9571240 - Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.

Kitamura K et al. Mol Biol Cell 1998 May;9(5):1065-80

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:11531413 - HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

Elder RT et al. Virology 2001 Sep 01;287(2):359-70

PMID:9950674 - Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.

Moynihan EB et al. Mol Biol Cell 1999 Feb;10(2):245-57

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:9398669 - A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.

Yamaguchi S et al. Mol Biol Cell 1997 Dec;8(12):2475-86

PMID:11313465 - Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.

Tanaka K et al. Mol Cell Biol 2001 May;21(10):3398-404

PMID:11683392 - Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

Cueille N et al. J Cell Sci 2001 Jul;114(Pt 14):2649-64

PMID:11739790 - Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast.

West RR et al. Mol Biol Cell 2001 Dec;12(12):3919-32

PMID:8455610 - Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.

Bueno A et al. Mol Cell Biol 1993 Apr;13(4):2286-97

PMID:11606526 - Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.

Liang DT et al. Genetics 2001 Oct;159(2):471-86

PMID:1825699 - Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase.

Featherstone C et al. Nature 1991 Feb 28;349(6312):808-11

PMID:2406029 - Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.

Enoch T et al. Cell 1990 Feb 23;60(4):665-73

PMID:14762117 - A novel RING-finger-like protein Ini1 is essential for cell cycle progression in fission yeast.

Oltra E et al. J Cell Sci 2004 Feb 29;117(Pt 6):967-74

PMID:10835386 - Slm9, a novel nuclear protein involved in mitotic control in fission yeast.

Kanoh J et al. Genetics 2000 Jun;155(2):623-31

PMID:1850698 - Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.

Parker LL et al. EMBO J 1991 May;10(5):1255-63

PMID:10392445 - Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation.

Grallert A et al. Yeast 1999 Jun 15;15(8):669-86

PMID:1756736 - The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Warbrick E et al. EMBO J 1991 Dec;10(13):4291-9

PMID:25492408 - Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.

Ruan K et al. Genes Cells 2015 Mar;20(3):160-72

PMID:24508166 - Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Deng L et al. Curr Biol 2014 Feb 17;24(4):428-33

PMID:32084401 - The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.

Basu S et al. Curr Biol 2020 Mar 09;30(5):883-892.e4

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:9001228 - A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.

Matsumoto T Mol Cell Biol 1997 Feb;17(2):742-50

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4933-41

PMID:33008060 - Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage.

Alao JP et al. Microorganisms 2020 Sep 30;8(10)

PMID:10462526 - The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited.

Beltraminelli N et al. J Cell Sci 1999 Sep;112 Pt 18:3103-14

PMID:9278510 - Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Furnari B et al. Science 1997 Sep 05;277(5331):1495-7

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:11270571 - A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.

Wan S et al. Curr Genet 2001 Jan;38(6):299-306

PMID:2474475 - cdc2 and the regulation of mitosis: six interacting mcs genes.

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PMID:7957098 - Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

Saka Y et al. EMBO J 1994 Nov 15;13(22):5319-29

PMID:30674555 - An essential role for dNTP homeostasis following CDK-induced replication stress.

Pai CC et al. J Cell Sci 2019 Mar 25;132(6)

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:15629716 - Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.

López-Avilés S et al. Mol Cell 2005 Jan 07;17(1):49-59

PMID:1703321 - Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.

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PMID:3796591 - Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.

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PB_REF:0000003 - Disease Association Curation

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:1448087 - The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

Ottilie S et al. Mol Cell Biol 1992 Dec;12(12):5571-80

PMID:3058333 - Multiple phosphorylated forms of the product of the fission yeast cell division cycle gene cdc2+.

Potashkin JA et al. Curr Genet 1988 Sep;14(3):235-40

PMID:9487130 - Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.

Dahlen M et al. Mol Biol Cell 1998 Mar;9(3):611-21

PMID:7982971 - mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15.

Lee MS et al. J Biol Chem 1994 Dec 02;269(48):30530-7

PMID:9430640 - Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.

Benito J et al. EMBO J 1998 Jan 15;17(2):482-97

PMID:8121488 - Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Moreno S et al. Nature 1994 Jan 20;367(6460):236-42

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:8497322 - Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

Walworth N et al. Nature 1993 May 27;363(6427):368-71

PMID:8515817 - Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase.

Parker LL et al. Nature 1993 Jun 24;363(6431):736-8

PMID:1427071 - Fission yeast genes involved in coupling mitosis to completion of DNA replication.

Enoch T et al. Genes Dev 1992 Nov;6(11):2035-46

PMID:12569356 - hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress.

Routhier EL et al. Oncogene 2003 Feb 06;22(5):637-48

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:28539404 - Analysis of interphase node proteins in fission yeast by quantitative and superresolution fluorescence microscopy.

Akamatsu M et al. Mol Biol Cell 2017 Nov 07;28(23):3203-3214

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

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PMID:7262540 - Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe.

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PMID:36413467 - Absence of Wee1 alters global transcriptional response to oxidative stress in Schizosaccharomyces pombe.

Datta S et al. FEMS Microbiol Lett 2022 Nov 25;369(1)

PMID:2544292 - Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control.

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PMID:8860233 - Forces acting on the fission yeast anaphase spindle.

Hagan IM et al. Cell Motil Cytoskeleton 1996;34(1):69-75

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:10581266 - The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts.

Muñoz MJ et al. Genetics 1999 Dec;153(4):1561-72

PMID:16049679 - Mpg1, a fission yeast protein required for proper septum structure, is involved in cell cycle progression through cell-size checkpoint.

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PMID:16611237 - Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes.

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PMID:24047646 - Pom1 and cell size homeostasis in fission yeast.

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PMID:31644361 - A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

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PMID:12234926 - Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.

Hirata D et al. EMBO J 2002 Sep 16;21(18):4863-74

PMID:28272970 - Wee1 and Cdc25: Tools, pathways, mechanisms, questions.

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PMID:21132016 - Yox1 links MBF-dependent transcription to completion of DNA synthesis.

Gómez-Escoda B et al. EMBO Rep 2011 Jan;12(1):84-9

PMID:1372994 - p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

Parker LL et al. Proc Natl Acad Sci U S A 1992 Apr 01;89(7):2917-21

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:29361524 - F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast.

Qiu C et al. J Cell Sci 2018 Feb 02;131(3)

PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.

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PMID:26918805 - Consequences of abnormal CDK activity in S phase.

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PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

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PMID:1165770 - Genetic control of cell size at cell division in yeast.

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PMID:8006074 - Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit.

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PMID:27398807 - Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

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PMID:22451489 - Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.

Szilagyi Z et al. Mol Cell Biol 2012 Jun;32(11):2099-109

PMID:24728197 - The basic leucine zipper domain transcription factor Atf1 directly controls Cdc13 expression and regulates mitotic entry independently of Wee1 and Cdc25 in Schizosaccharomyces pombe.

Bandyopadhyay S et al. Eukaryot Cell 2014 Jun;13(6):813-21

PMID:33683349 - The fission yeast S-phase cyclin Cig2 can drive mitosis.

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PMID:17804800 - Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.

Murakami-Tonami Y et al. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14688-93

PMID:11298745 - Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

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PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

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PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.

Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7

PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

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PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

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PMID:3955656 - cdc25+ functions as an inducer in the mitotic control of fission yeast.

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PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:8573795 - RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.

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PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

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PMID:24861625 - Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Mahyous Saeyd SA et al. Nucleic Acids Res 2014 Jul;42(12):7734-47

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

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PMID:35354597 - Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe .

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PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

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PMID:9524127 - Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.

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PMID:8256510 - Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells.

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PMID:29930085 - Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.

Tay YD et al. J Cell Sci 2018 Jul 19;131(14)

PMID:10462529 - Translational control of the cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth.

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PMID:30806623 - Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast.

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PMID:7845361 - Ethanol-hypersensitive and ethanol-dependent cdc- mutants in Schizosaccharomyces pombe.

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PMID:9154809 - A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.

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PMID:14985109 - Cdk inhibitor ste9p/srw1p is involved in response to protein synthesis inhibition in fission yeast.

Sakai T Biochem Biophys Res Commun 2004 Mar 19;315(4):984-90

PMID:23333317 - Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.

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PMID:24506453 - The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.

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PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

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PMID:12455694 - mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.

Williams DR et al. Eukaryot Cell 2002 Oct;1(5):758-73

PMID:11029045 - A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.

Tournier S et al. Mol Biol Cell 2000 Oct;11(10):3411-24

PMID:17998401 - Nuclear size control in fission yeast.

Neumann FR et al. J Cell Biol 2007 Nov 19;179(4):593-600

PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:11085271 - spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis.

Samuel JM et al. Mol Gen Genet 2000 Oct;264(3):306-16

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:9843577 - The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe.

Breeding CS et al. Mol Biol Cell 1998 Dec;9(12):3399-415

PMID:26093291 - Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.

Habib AG et al. Biochem Biophys Res Commun 2015 Aug 14;464(1):140-6

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)

PMID:11711540 - The Ded1 DEAD box helicase interacts with Chk1 and Cdc2.

Liu HY et al. J Biol Chem 2002 Jan 25;277(4):2637-43

PMID:6828164 - Control of timing of cell cycle events in fission yeast by the wee 1+ gene.

Fantes PA Nature 1983 Mar 10;302(5904):153-5

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:11707530 - Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe.

Huang HK et al. J Cell Sci 2001 Oct;114(Pt 20):3779-88

PMID:15975911 - The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis.

Ge W et al. Mol Biol Cell 2005 Sep;16(9):4124-38

PMID:12093738 - G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.

Zarzov P et al. EMBO J 2002 Jul 01;21(13):3370-6

PMID:20876564 - Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Lahoz A et al. Genetics 2010 Dec;186(4):1261-70

PMID:22665807 - Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches.

Lu LX et al. Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9899-904

PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.

Stonyte V et al. iScience 2020 May 22;23(5):101063

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