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protein coding gene - ism1 (SPCC18B5.08c) - mitochondrial isoleucine-tRNA ligase

Gene summary

Standard name
ism1
Systematic ID
SPCC18B5.08c
Product
mitochondrial isoleucine-tRNA ligase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USL3
ORFeome ID
47/47E04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 733336..736415 reverse strand

Annotation

PBO:0003598 - 6.1.1.5

Disease association

MONDO:0014455 - cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome

References:

GO biological process

GO:0106074 - aminoacyl-tRNA metabolism involved in translational fidelity

References:

GO:0032543 - mitochondrial translation

References:

GO:0070127 - tRNA aminoacylation for mitochondrial protein translation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0002161 - aminoacyl-tRNA deacylase activity

References:

GO:0005524 - ATP binding

References:

GO:0004822 - isoleucine-tRNA ligase activity

References:

GO:0000049 - tRNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00133tRNA-synt_1aa-tRNA-synth_IaPfam
PF08264Anticodon_1M/V/L/I-tRNA-synth_anticd-bdPfam
cd00818IleRS_coreCDD
cd07960Anticodon_Ia_Ile_BEmAnticodon_Ile_BEmCDD
PS00178AA_TRNA_LIGASE_Iaa-tRNA-synth_I_CSPROSITE patterns
PR00984TRNASYNTHILEIle-tRNA-ligasePRINTS
G3DSA:3.40.50.620:FF:000111CATH-FunFam
G3DSA:1.10.730.20CATH-Gene3D
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
G3DSA:3.90.740.10Val/Leu/Ile-tRNA-synth_editCATH-Gene3D
SSF47323tRNAsynth_Ia_anticodon-bdSUPERFAMILY
SSF50677Val/Leu/Ile-tRNA-synth_editSUPERFAMILY
SSF52374SUPERFAMILY
PTHR42765Ile-tRNA_ligasePANTHER
TIGR00392ileSIle-tRNA-ligaseNCBIFAM
MF_02002Ile_tRNA_synth_type1Ile-tRNA-ligase_type1HAMAP

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053