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protein coding gene - thc1 (SPCC18B5.09c) - RRM RNA binding protein involved in snRNA processing Thc1

Gene summary

Standard name
thc1
Systematic ID
SPCC18B5.09c
Product
RRM RNA binding protein involved in snRNA processing Thc1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USL2
ORFeome ID
02/02C04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 737089..737870 reverse strand

Annotation

GO biological process

GO:0016180 - snRNA processing

References:

GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0005732 - sno(s)RNA-containing ribonucleoprotein complex

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Modification

MOD:01148 - ubiquitinylated lysine

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002133 - abolished protein-RNA interaction

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Genotypes:

FYPO:0008110 - decreased U6 2'-O-snRNA methylation at residue A64

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0000199 - previously annotated as dubious

Protein features

IDNameInterPro nameDB name
PF22877RRM_Thc1Thc1_RRMPFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37403782 - The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA.
Porat J et al. Nucleic Acids Res 2023 Sep 08;51(16):8805-8819
PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
Porat J et al. Nat Commun 2022 Mar 11;13(1):1277
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053