protein coding gene - acs1 (SPCC191.02c) - acetyl-CoA ligase

Gene summary

Standard name: acs1
Systematic ID: SPCC191.02c
Product: acetyl-CoA ligase
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPCC417.14c
UniProt ID: P78773
ORFeome ID: 27/27C09
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 1708234..1711217 reverse strand

Annotation

PBO:0005603 - 6.2.1.1

GO biological process

GO:0006085 - acetyl-CoA biosynthetic process

References:

GO_REF:0000033

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:23091701

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000024

GO:0005634 - nucleus

References:

GO molecular function

GO:0003987 - acetyl-CoA synthetase activity

References:

GO_REF:0000033

GO:0016208 - AMP binding

References:

GO_REF:0000002

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

PMID:25720772

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002151 - inviable spore

References:

PMID:27887640

Genotypes:

acs1delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30099677

Genotypes:

acs1delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

acs1delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

acs1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00501	AMP-binding	AMP-dep_synth/lig_dom	Pfam
PF13193	AMP-binding_C	AMP-bd_C	Pfam
PF16177	ACAS_N	ACAS_N	Pfam
cd05966	ACS		CDD
PS00455	AMP_BINDING	AMP-binding_CS	PROSITE patterns
G3DSA:3.40.50.12780:FF:000001			CATH-FunFam
G3DSA:3.30.300.30		AMP-b_sf	CATH-Gene3D
G3DSA:3.40.50.12780		ANL_N_sf	CATH-Gene3D
SSF56801			SUPERFAMILY
PTHR24095			PANTHER
NF001208	PRK00174.1		NCBIFAM
TIGR02188	Ac_CoA_lig_AcsA	Ac_CoA_lig	NCBIFAM

Orthologs

ACSS1 (HGNC:16091) Homo sapiens
acs1 (SJAG_02741) Schizosaccharomyces japonicus
ACS1 (YAL054C) Saccharomyces cerevisiae
ACS2 (YLR153C) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:42567156 - Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases.: Li M et al. Structure 2026 Aug 07;
GO_REF:0000002 - Comments
PMID:20519959 - S. pombe genome deletion project: an update.: Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.: Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.: Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:18257517 - Phosphoproteome analysis of fission yeast.: Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .: Budden AM et al. Elife 2023 Aug 24;12
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.: Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23091701 - Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.: Nakamura T et al. Open Biol 2012 Sep;2(9):120117