protein coding gene - cyc1 (SPCC191.07) - cytochrome c

Gene summary

Standard name

cyc1

Systematic ID

SPCC191.07

Product

cytochrome c

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P00046

ORFeome ID

01/01H05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1714622..1715798 forward strand

Annotation

Protein features

Orthologs

• CYCS (HGNC:19986) Homo sapiens
• cyc1 (SJAG_02744) Schizosaccharomyces japonicus
• CYC7 (YEL039C) Saccharomyces cerevisiae
• CYC1 (YJR048W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:9372932 - The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor.

McNabb DS et al. Mol Cell Biol 1997 Dec;17(12):7008-18

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.

Miki R et al. FEBS J 2008 Nov;275(21):5309-24

PMID:18223116 - Key function for the CCAAT-binding factor Php4 to regulate gene expression in response to iron deficiency in fission yeast.

Mercier A et al. Eukaryot Cell 2008 Mar;7(3):493-508

PB_REF:0000003 - Disease Association Curation

PMID:23832353 - The fission yeast php2 mutant displays a lengthened chronological lifespan.

Takuma K et al. Biosci Biotechnol Biochem 2013;77(7):1548-55

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:19120452 - Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe.

Cui TZ et al. FEBS J 2009 Feb;276(3):748-59

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:207525 - Cytochrome c from Schizosaccharomyces pombe. 2. Amino-acid sequence.

Simon-Becam AM et al. Eur J Biochem 1978 May 16;86(2):407-16

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:6287225 - Structure of the Schizosaccharomyces pombe cytochrome c gene.

Russell PR et al. Mol Cell Biol 1982 Feb;2(2):106-16

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27664110 - Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.

Delerue T et al. FEBS Lett 2016 Oct;590(20):3544-3558

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D et al. PLoS One 2012;7(1):e29765

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:33202882 - The Fission Yeast RNA-Binding Protein Meu5 Is Involved in Outer Forespore Membrane Breakdown during Spore Formation.

Zhang B et al. J Fungi (Basel) 2020 Nov 13;6(4)

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.

Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63

GO_REF:0000002 - Comments

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380