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protein coding gene - inv1 (SPCC191.11) - external invertase, beta-fructofuranosidase Inv1

Gene summary

Standard name
inv1
Systematic ID
SPCC191.11
Product
external invertase, beta-fructofuranosidase Inv1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59852
ORFeome ID
45/45G05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1723434..1726164 forward strand

Annotation

PBO:0002029 - 3.2.1.26

GO biological process

GO:0005987 - sucrose catabolic process

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005576 - extracellular region

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GO molecular function

GO:0004564 - beta-fructofuranosidase activity

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GO:0004575 - sucrose alpha-glucosidase activity

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Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

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Modification

MOD:00693 - glycosylated residue

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MOD:00006 - N-glycosylated residue

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007675 - abolished cell population growth on sucrose carbon source

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Genotypes:

FYPO:0007673 - abolished invertase activity

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0001177 - decreased cell population growth on trehalose carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0001175 - normal growth on maltose carbon source

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Genotypes:

FYPO:0001174 - normal growth on sucrose carbon source

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000077 - resistance to rapamycin

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Genotypes:

FYPO:0000440 - sensitive to antimycin A

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF08244Glyco_hydro_32CGlyco_hydro_32_CPFAM
PF00251Glyco_hydro_32NGlyco_hydro_32_NPFAM
cd18622GH32_Inu-likeCDD
PS00609GLYCOSYL_HYDROL_F32Glyco_hydro_32_ASPROSITE_PATTERNS
SM00640glyco_32Glyco_hydro_32SMART
G3DSA:2.115.10.20:FF:000002FUNFAM
SSF75005Arabinanase/levansucrase/invertaseGlyco_hydro_beta-prop_sfSUPERFAMILY
SSF49899Concanavalin A-like lectins/glucanasesConA-like_dom_sfSUPERFAMILY
G3DSA:2.60.120.560GENE3D
G3DSA:2.115.10.20Glycosyl hydrolase domain; family 43Glyco_hydro_beta-prop_sfGENE3D
PTHR42800EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)PANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:27481777 - Identification of nuclear genes affecting 2-Deoxyglucose resistance in Schizosaccharomyces pombe.
Vishwanatha A et al. FEMS Yeast Res 2016 Sep;16(6)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22416758 - Mpg2 interacts and cooperates with Mpg1 to maintain yeast glycosylation.
Muñoz-Centeno MC et al. FEMS Yeast Res 2012 Aug;12(5):511-20
PMID:33536395 - The fission yeast gmn2 + gene encodes an ERD1 homologue of Saccharomyces cerevisiae required for protein glycosylation and retention of luminal endoplasmic reticulum proteins.
Tanaka N et al. J Gen Appl Microbiol 2021 Jun 03;67(2):67-76
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:2187435 - Purification and characterization of the invertase from Schizosaccharomyces pombe. A comparative analysis with the invertase from Saccharomyces cerevisiae.
Moreno S et al. Biochem J 1990 May 01;267(3):697-702
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Murai T et al. Genetics 2009 Oct;183(2):517-27
PMID:20622008 - A chromatin-remodeling protein is a component of fission yeast mediator.
Khorosjutina O et al. J Biol Chem 2010 Sep 24;285(39):29729-37
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
Nakase Y et al. Genetics 2006 Jun;173(2):569-78
PMID:16049679 - Mpg1, a fission yeast protein required for proper septum structure, is involved in cell cycle progression through cell-size checkpoint.
Donoso I et al. Mol Genet Genomics 2005 Sep;274(2):155-67
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:2112088 - The ryh1 gene in the fission yeast Schizosaccharomyces pombe encoding a GTP-binding protein related to ras, rho and ypt: structure, expression and identification of its human homologue.
Hengst L et al. EMBO J 1990 Jun;9(6):1949-55
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22140232 - Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.
Matsuzawa T et al. Eukaryot Cell 2012 Feb;11(2):159-67
PMID:11136464 - Functional characterization of the alpha-glucoside transporter Sut1p from Schizosaccharomyces pombe, the first fungal homologue of plant sucrose transporters.
Reinders A et al. Mol Microbiol 2001 Jan;39(2):445-54
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:9535817 - Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe.
Tanaka N et al. Biochem Biophys Res Commun 1998 Apr 07;245(1):246-53