PomBase - protein coding gene - tif6 (SPCC1919.09) - translation initiation factor-like ribosome biogenesis protein - The Schizosaccharomyces pombe genome database

ID	Name	InterPro name	DB name
PF01912	eIF-6	eIF6	PFAM
cd00527	IF6	eIF6	CDD
SM00654	eIF6neu2	eIF6	SMART
G3DSA:3.75.10.10:FF:000001			FUNFAM
SSF55909	Pentein		SUPERFAMILY
G3DSA:3.75.10.10			GENE3D
PTHR10784	TRANSLATION INITIATION FACTOR 6	eIF6	PANTHER
PIRSF006413	Transl_init_IF-6	eIF6	PIRSF
MF_00032	eIF_6	eIF6	HAMAP
TIGR00323	eIF-6	eIF6	NCBIFAM

References / Literature

PMID:36423630 - Chromatin localization of nucleophosmin organizes ribosome biogenesis.: Ugolini I et al. Mol Cell 2022 Dec 01;82(23):4443-4457.e9
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.: Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.: Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.: Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.: Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.: Zhang K et al. Science 2011 Mar 25;331(6024):1624-7

protein coding gene - tif6 (SPCC1919.09) - translation initiation factor-like ribosome biogenesis protein

Gene summary

Annotation

GO biological process

GO:1902626 - assembly of large subunit precursor of preribosome

GO:0000460 - maturation of 5.8S rRNA

GO:0000470 - maturation of LSU-rRNA

GO:0000054 - ribosomal subunit export from nucleus

GO cellular component

GO:0005829 - cytosol

GO:0005634 - nucleus

GO:0030684 - preribosome

GO molecular function

GO:0043023 - ribosomal large subunit binding

Modification

MOD:00046 - O-phospho-L-serine

MOD:01149 - sumoylated lysine

MOD:01148 - ubiquitinylated lysine

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

PomGeneEx:0000012 - RNA level decreased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

FYPO:0002177 - viable vegetative cell with normal cell morphology

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature