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protein coding gene - mug137 (SPCC1919.11) - BAR adaptor protein, human endophilin A3-like

Gene summary

Standard name
mug137
Systematic ID
SPCC1919.11
Product
BAR adaptor protein, human endophilin A3-like
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94478
ORFeome ID
25/25H12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 2231761..2233381 forward strand

Annotation

Comment

PBO:0091288 - meiosis specific splicing

References:

GO biological process

GO:0072583 - clathrin-dependent endocytosis

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0008289 - lipid binding

References:

GO:0180020 - membrane bending activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein features

PBO:0111772 - BAR domain

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00018SH3_1SH3_domainPfam
PF03114BARBAR_domPfam
cd00174SH3CDD
cd07593BAR_MUG137_fungiCDD
PS50002SH3SH3_domainPROSITE profiles
PS51021BARBAR_domPROSITE profiles
SM00326SH3SH3_domainSMART
SM00721BARBAR_domSMART
G3DSA:1.20.1270.60:FF:000174CATH-FunFam
G3DSA:2.30.30.40:FF:000418CATH-FunFam
G3DSA:1.20.1270.60AH/BAR_dom_sfCATH-Gene3D
G3DSA:2.30.30.40CATH-Gene3D
SSF103657AH/BAR_dom_sfSUPERFAMILY
SSF50044SH3-like_dom_sfSUPERFAMILY
PTHR45929STAMPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:33268381 - Endophilin recruitment drives membrane curvature generation through coincidence detection of GPCR loop interactions and negative lipid charge.
Mondal S et al. J Biol Chem 2021;296:100140
PMID:15893732 - Negative control contributes to an extensive program of meiotic splicing in fission yeast.
Averbeck N et al. Mol Cell 2005 May 13;18(4):491-8
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105