protein coding gene - bdp1 (SPCC1919.14c) - transcription factor TFIIIB complex subunit Bdp1

Gene summary

Standard name: bdp1
Systematic ID: SPCC1919.14c
Product: transcription factor TFIIIB complex subunit Bdp1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: spB''
UniProt ID: O94481
ORFeome ID: 34/34G06
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 2237405..2239355 reverse strand

Annotation

Disease association

MONDO:0032639 - hearing loss, autosomal recessive 112

References:

PB_REF:0000006

GO biological process

GO:0070898 - RNA polymerase III preinitiation complex assembly

References:

GO_REF:0000033

GO cellular component

GO:0005634 - nucleus

References:

PMID:16823372

GO:0000126 - transcription factor TFIIIB complex

References:

GO_REF:0000033

GO molecular function

GO:0003677 - DNA binding

References:

GO_REF:0000050

GO:0000995 - RNA polymerase III general transcription initiation factor activity

References:

GO_REF:0000111

GO:0001156 - TFIIIC-class transcription factor complex binding

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

PMID:25720772

MOD:01149 - sumoylated lysine

References:

Protein features

PBO:0111844 - Myb family

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:33313903

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000046 - decreased cell population growth

References:

PMID:23695302

Genotypes:

bdp1+(wild type)[Overexpression]

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

bdp1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

bdp1delta

FYPO:0001492 - viable elongated vegetative cell

References:

PMID:23695302

Genotypes:

bdp1+(wild type)[Overexpression]

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF15963	Myb_DNA-bind_7	TFIIIB_B''_Myb	PFAM
cd00167	SANT	SANT/Myb	CDD
PS51293	SANT	SANT_dom	PROSITE_PROFILES
SM00717	sant	SANT/Myb	SMART
SSF46689	Homeodomain-like	Homeodomain-like_sf	SUPERFAMILY
G3DSA:1.10.10.60			GENE3D
PTHR22929	RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B		PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolyte	disorder_prediction		MOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

Orthologs

BDP1 (HGNC:13652) Homo sapiens
bdp1 (SJAG_03007) Schizosaccharomyces japonicus
BDP1 (YNL039W) Saccharomyces cerevisiae

References / Literature

PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.: Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.: Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.: Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.: Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.: Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.: Nie M et al. Sci Rep 2015 Sep 25;5:14389
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7