protein coding gene - tel1 (SPCC23B6.03c) - ATM checkpoint kinase

Gene summary

Standard name

tel1

Systematic ID

SPCC23B6.03c

Product

ATM checkpoint kinase

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74630

ORFeome ID

34/34D04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1268573..1277541 reverse strand

Annotation

Protein features

Orthologs

• ATM (HGNC:795) Homo sapiens
• tel1 (SJAG_03720) Schizosaccharomyces japonicus
• TEL1 (YBL088C) Saccharomyces cerevisiae

References / Literature

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:27229179 - Structure of the intact ATM/Tel1 kinase.

Wang X et al. Nat Commun 2016 May 27;7:11655

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:24806815 - Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function.

Wei Y et al. PLoS One 2014;9(5):e97028

PMID:11226171 - Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

Manolis KG et al. EMBO J 2001 Jan 15;20(1-2):210-21

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10430579 - Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+).

Matsuura A et al. Genetics 1999 Aug;152(4):1501-12

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:22797921 - Heat induction of a novel Rad9 variant from a cryptic translation initiation site reduces mitotic commitment.

Janes S et al. J Cell Sci 2012 Oct 01;125(Pt 19):4487-97

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70

PMID:17209013 - Role of SUMO in the dynamics of telomere maintenance in fission yeast.

Xhemalce B et al. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):893-8

PMID:31262821 - Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks.

Feng G et al. Proc Natl Acad Sci U S A 2019 Jul 16;116(29):14563-14572

PMID:40128540 - Asymmetric activation of dimeric ATM/Tel1 kinase.

Wang P et al. Cell Discov 2025 Mar 25;11(1):30

PMID:20505337 - Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

Khair L et al. Cell Cycle 2010 Jun 01;9(11):2237-48

PMID:21561865 - The phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.

Yue M et al. J Biol Chem 2011 Jul 01;286(26):22864-74

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

PMID:20140190 - A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.

Subramanian L et al. PLoS Genet 2010 Feb 05;6(2):e1000839

PMID:9771717 - Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

Naito T et al. Nat Genet 1998 Oct;20(2):203-6

PMID:24312672 - A quality control mechanism linking meiotic success to release of ascospores.

Guo H et al. PLoS One 2013;8(12):e82758

PMID:24493214 - ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

Deshpande RA et al. EMBO J 2014 Mar 03;33(5):482-500

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:29851556 - Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.

Limbo O et al. Mol Biol Cell 2018 Jun 01;29(11):1389-1399

PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.

Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55

PMID:19197239 - Tdp1 protects against oxidative DNA damage in non-dividing fission yeast.

Ben Hassine S et al. EMBO J 2009 Mar 18;28(6):632-40

PMID:21098122 - Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O et al. Mol Cell Biol 2011 Feb;31(3):573-83

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:12589755 - The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Kanoh J et al. J Mol Biol 2003 Feb 28;326(4):1081-94

PMID:12944482 - The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.

Chahwan C et al. Mol Cell Biol 2003 Sep;23(18):6564-73

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94

PMID:22761595 - The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.

Lin SJ et al. PLoS Genet 2012 Jun;8(6):e1002801

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:26746798 - Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast.

Xu YJ Cell Signal 2016 Apr;28(4):235-45

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:19714219 - Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.

Moser BA et al. PLoS Genet 2009 Aug;5(8):e1000622

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22101932 - Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Moser BA et al. Nat Struct Mol Biol 2011 Nov 20;18(12):1408-13

PMID:15155581 - Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.

Furuya K et al. Genes Dev 2004 May 15;18(10):1154-64

PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:22302936 - Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.

Yamazaki H et al. Genes Dev 2012 Feb 01;26(3):241-6

PMID:15964794 - ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

You Z et al. Mol Cell Biol 2005 Jul;25(13):5363-79

PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.

Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867

PMID:14585996 - Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.

Zhao H et al. Mol Cell Biol 2003 Nov;23(22):8395-403

PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.

Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86

PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.

Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)

PMID:21084840 - The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.

Tougan T et al. Cell Cycle 2010 Dec 01;9(23):4688-702

PMID:16618806 - Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast.

Xu YJ et al. Genes Dev 2006 Apr 15;20(8):990-1003