PomBase home

protein coding gene - pog1 (SPCC24B10.22) - mitochondrial DNA polymerase, gamma subunit Pog1

Gene summary

Standard name
pog1
Systematic ID
SPCC24B10.22
Product
mitochondrial DNA polymerase, gamma subunit Pog1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCPB16A4.01
UniProt ID
Q12704
ORFeome ID
49/49F06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 941115..944722 forward strand

Annotation

PBO:0000444 - 2.7.7.7

Disease association

MONDO:0044970 - mitochondrial disease

References:

MONDO:0008758 - mitochondrial DNA depletion syndrome 4a

References:

MONDO:0013350 - mitochondrial DNA depletion syndrome 4b

References:

MONDO:0024528 - progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1

References:

MONDO:0009783 - progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 1

References:

MONDO:0011835 - sensory ataxic neuropathy, dysarthria, and ophthalmoparesis

References:

GO biological process

GO:0071897 - DNA biosynthetic process

References:

GO:0006264 - mitochondrial DNA replication

References:

GO cellular component

GO:0005760 - gamma DNA polymerase complex

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0003677 - DNA binding

References:

GO:0003887 - DNA-directed DNA polymerase activity

References:

GO:0008310 - single-stranded DNA 3'-5' DNA exonuclease activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000359 - abnormal mitochondrial morphology

References:

Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0003769 - decreased cellular mtDNA level

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001406 - increased septum thickness

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0004987 - sensitive to sunitinib

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0001119 - tapered vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00476DNA_pol_ADNA-dir_DNA_pol_A_palm_domPfam
PF18136DNApol_ExoDNApol_ExoPfam
cd08641DNA_pol_gammaAPOLG_palm_domCDD
SM00482POLAcDNA-dir_DNA_pol_A_palm_domSMART
PR00867DNAPOLGDNA-dir_DNA_pol_A_mtPRINTS
G3DSA:1.10.150.20:FF:000035CATH-FunFam
G3DSA:3.30.420.390:FF:000003CATH-FunFam
G3DSA:1.10.150.20CATH-Gene3D
G3DSA:3.30.420.390CATH-Gene3D
G3DSA:3.30.70.370CATH-Gene3D
SSF53098RNaseH-like_sfSUPERFAMILY
SSF56672DNA/RNA_pol_sfSUPERFAMILY
PTHR10267DNA-dir_DNA_pol_A_mtPANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:17868468 - Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome.
Chu Z et al. BMC Genomics 2007 Sep 15;8:323
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:9034326 - Mitochondrial DNA polymerases from yeast to man: a new family of polymerases.
Lecrenier N et al. Gene 1997 Jan 31;185(1):147-52
PMID:26385865 - Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.
Kim DM et al. Toxicol Sci 2016 Jan;149(1):4-14
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:8628681 - The gamma subfamily of DNA polymerases: cloning of a developmentally regulated cDNA encoding Xenopus laevis mitochondrial DNA polymerase gamma.
Ye F et al. Nucleic Acids Res 1996 Apr 15;24(8):1481-8
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:7489897 - Characterization of a new DNA polymerase from Schizosaccharomyces pombe: a probable homologue of the Saccharomyces cerevisiae DNA polymerase gamma.
Ropp PA et al. Gene 1995 Nov 07;165(1):103-7