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protein coding gene - SPCC285.04 - transthyretin/hydroxyisourate hydrolase

Gene summary

Systematic ID
SPCC285.04
Product
transthyretin/hydroxyisourate hydrolase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74492
ORFeome ID
02/02G02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1800785..1801508 forward strand

Annotation

Disease association

MONDO:0971004 - amyloidosis, hereditary systemic 1

References:

MONDO:0020730 - carpal tunnel syndrome 1

References:

MONDO:0007100 - familial amyloid neuropathy

References:

MONDO:0007785 - hyperthyroxinemia, dystransthyretinemic

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MONDO:0005071 - nervous system disorder

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GO biological process

GO:0006144 - purine nucleobase metabolic process

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GO:0019628 - urate catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0033971 - hydroxyisourate hydrolase activity

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00576TransthyretinTransthyretin/HIU_hydrolase_dPfam
cd05822TLP_HIUaseHydroxyisourate_hydrolaseCDD
PS00768TRANSTHYRETIN_1Thyroxine_BSPROSITE patterns
PS00769TRANSTHYRETIN_2Transthyretin_CSPROSITE patterns
SM00095TR_THYTransthyretin/HIU_hydrolase_dSMART
PR00189TRNSTHYRETINTransthyretin/HIU_hydrolasePRINTS
G3DSA:2.60.40.180Transthyretin/HIU_hydrolase_sfCATH-Gene3D
SSF49472Transthyretin/HIU_hydrolase_sfSUPERFAMILY
PTHR10395Transthyretin/HIU_hydrolase_dPANTHER
TIGR02962hdxy_isourateHydroxyisourate_hydrolaseNCBIFAM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
Guydosh NR et al. Elife 2017 Sep 25;6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PB_REF:0000003 - Disease Association Curation
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:26610878 - Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis.
Gertz MA et al. J Am Coll Cardiol 2015 Dec 01;66(21):2451-2466
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623