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protein coding gene - wtf18 (SPCC285.07c) - wtf antidote-like meiotic drive suppressor Wtf18

Gene summary

Standard name
wtf18
Systematic ID
SPCC285.07c
Product
wtf antidote-like meiotic drive suppressor Wtf18
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
wts1817a, wtf5
UniProt ID
O74495
Characterisation status
meiotic driver
Feature type
mRNA gene
Genomic location
chromosome III: 1806589..1808534 reverse strand

Annotation

GO biological process

GO:0110134 - meiotic drive

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GO cellular component

GO:0072324 - ascus epiplasm

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GO:0005737 - cytoplasm

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GO:0005789 - endoplasmic reticulum membrane

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GO:0140549 - spore inner membrane

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GO:0005774 - vacuolar membrane

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Modification

MOD:00047 - O-phospho-L-threonine

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Protein features

PBO:0111903 - wtf element

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006793 - altered meiotic drive suppression specificity

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Genotypes:

FYPO:0001489 - inviable vegetative cell

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Genotypes:

FYPO:0006790 - meiotic drive suppression

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Genotypes:

FYPO:0000590 - normal sporulation

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

Taxonomic conservation

PBO:0016878 - Schizosaccharomyces pombe specific

Warnings

PBO:0000070 - gene structure updated

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Protein features

IDNameInterPro nameDB name
PF03303WTFWTFPfam
Transmembrane alpha helixDeepTMHMM

References / Literature

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:12952871 - Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe.
Bowen NJ et al. Genome Res 2003 Sep;13(9):1984-97
PMID:28631610 - A large gene family in fission yeast encodes spore killers that subvert Mendel's law.
Hu W et al. Elife 2017 Jun 20;6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30475921 - A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote.
Bravo Núñez MA et al. PLoS Genet 2018 Nov;14(11):e1007836
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:38097609 - Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers.
Zheng JX et al. Nat Commun 2023 Dec 14;14(1):8334
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:32032353 - Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.
Bravo Núñez MA et al. PLoS Genet 2020 Feb;16(2):e1008350
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30991417 - Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.
Eickbush MT et al. Mol Biol Evol 2019 Jun 01;36(6):1201-1214