protein coding gene - cgs2 (SPCC285.09c) - dual-specificity cAMP/cGMP phosphodiesterase Cgs2

Gene summary

Standard name

cgs2

Systematic ID

SPCC285.09c

Product

dual-specificity cAMP/cGMP phosphodiesterase Cgs2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pde1

UniProt ID

P36599

ORFeome ID

25/25F07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1810337..1812643 reverse strand

Annotation

Protein features

Orthologs

• cgs2 (SJAG_02481) Schizosaccharomyces japonicus
• PDE1 (YGL248W) Saccharomyces cerevisiae

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24928510 - Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.

Cohen A et al. J Biol Chem 2014 Aug 01;289(31):21727-37

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:8392846 - The Schizosaccharomyces pombe pde1/cgs2 gene encodes a cyclic AMP phosphodiesterase.

Matviw H et al. Biochem Biophys Res Commun 1993 Jul 15;194(1):79-82

PMID:1340462 - Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.

Isshiki T et al. Genes Dev 1992 Dec;6(12B):2455-62

PMID:15448137 - Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+.

Davidson MK et al. J Biol Chem 2004 Dec 03;279(49):50857-63

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:9917066 - Molecular genetic analysis of U2AF59 in Schizosaccharomyces pombe: differential sensitivity of introns to mutational inactivation.

Romfo CM et al. RNA 1999 Jan;5(1):49-65

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:8918880 - 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.

Yamashita YM et al. Nature 1996 Nov 21;384(6606):276-9

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:11461899 - Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS et al. J Biol Chem 2001 Oct 26;276(43):40190-201

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Hatano T et al. Cell Cycle 2015;14(6):848-56

PMID:10526233 - Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.

Yamashita YM et al. Genes Cells 1999 Aug;4(8):445-63

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:1318497 - Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast.

Mochizuki N et al. Mol Gen Genet 1992 May;233(1-2):17-24

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:30301783 - The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.

Nakase Y et al. J Cell Sci 2018 Nov 21;131(22)

PMID:15831585 - Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

Ivey FD et al. Proc Natl Acad Sci U S A 2005 Apr 26;102(17):6108-13

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049

PMID:21118717 - Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.

Demirbas D et al. Cell Signal 2011 Mar;23(3):594-601

PMID:7816619 - Cloning of cDNAs from Arabidopsis thaliana that encode putative protein phosphatase 2C and a human Dr1-like protein by transformation of a fission yeast mutant.

Kuromori T et al. Nucleic Acids Res 1994 Dec 11;22(24):5296-301

PMID:8536311 - Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.

Kunitomo H et al. Curr Genet 1995 Jun;28(1):32-8

PMID:9710608 - The role of fnx1, a fission yeast multidrug resistance protein, in the transition of cells to a quiescent G0 state.

Dimitrov K et al. Mol Cell Biol 1998 Sep;18(9):5239-46

PMID:8227198 - Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.

Byrne SM et al. J Cell Sci 1993 Aug;105 ( Pt 4)(0 4):1095-100

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:7862141 - The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.

Wu SY et al. Mol Cell Biol 1995 Mar;15(3):1479-88

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model