protein coding gene - cnd2 (SPCC306.03c) - condensin complex non-SMC subunit Cnd2

Gene summary

Standard name

cnd2

Systematic ID

SPCC306.03c

Product

condensin complex non-SMC subunit Cnd2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9Y7R3

ORFeome ID

38/38A10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 409354..412091 reverse strand

Annotation

Protein features

Orthologs

• NCAPH (HGNC:1112) Homo sapiens
• cnd2 (SJAG_00768) Schizosaccharomyces japonicus
• BRN1 (YBL097W) Saccharomyces cerevisiae

References / Literature

PMID:12000947 - Cell biology: keeping the genome in shape.

Uhlmann F Nature 2002 May 09;417(6885):135-6

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:33468217 - Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.

Weigt M et al. Epigenetics Chromatin 2021 Jan 19;14(1):8

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.

Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.

Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67

PMID:19454013 - Conserved features of cohesin binding along fission yeast chromosomes.

Schmidt CK et al. Genome Biol 2009;10(5):R52

PMID:15148393 - Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin.

Chen ES et al. Proc Natl Acad Sci U S A 2004 May 25;101(21):8078-83

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37820734 - Establishment of dsDNA-dsDNA interactions by the condensin complex.

Tang M et al. Mol Cell 2023 Nov 02;83(21):3787-3800.e9

PMID:28988770 - Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.

Kschonsak M et al. Cell 2017 Oct 19;171(3):588-600.e24

PMID:25798942 - The Fun30 chromatin remodeler Fft3 controls nuclear organization and chromatin structure of insulators and subtelomeres in fission yeast.

Steglich B et al. PLoS Genet 2015 Mar;11(3):e1005101

PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.

Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807

PMID:29735745 - Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.

Schiklenk C et al. J Cell Biol 2018 Jul 02;217(7):2383-2401

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25778919 - Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction.

Reyes C et al. J Cell Biol 2015 Mar 16;208(6):713-27

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.

Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:27737959 - Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.

Martin CA et al. Genes Dev 2016 Oct 01;30(19):2158-2172

PMID:11554922 - Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair.

Morishita J et al. Genes Cells 2001 Sep;6(9):743-63

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.

Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)

PMID:25520186 - ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.

Akai Y et al. Open Biol 2014 Dec;4(12)

PMID:10485849 - Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.

Sutani T et al. Genes Dev 1999 Sep 01;13(17):2271-83

PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y et al. Open Biol 2011 Dec;1(4):110023

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X et al. PLoS One 2015;10(3):e0119347

PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.

Aono N et al. Nature 2002 May 09;417(6885):197-202

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.

Tsunemine S et al. Genetics 2025 Mar 25;

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:27266525 - Nucleosome eviction in mitosis assists condensin loading and chromosome condensation.

Toselli-Mollereau E et al. EMBO J 2016 Jul 15;35(14):1565-81

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827