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protein coding gene - sec2301 (SPCC31H12.07) - COPII vesicle coat, GAP for Sar1, Sec23a

Gene summary

Standard name
sec2301
Systematic ID
SPCC31H12.07
Product
COPII vesicle coat, GAP for Sar1, Sec23a
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sec23a, SPCC5E4.01, sec231
UniProt ID
O74873
ORFeome ID
28/28G09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 634267..636996 forward strand

Annotation

Disease association

MONDO:0009134 - congenital dyserythropoietic anemia type 2

References:

MONDO:0014802 - Cowden syndrome 7

References:

MONDO:0011911 - craniolenticulosutural dysplasia

References:

GO biological process

GO:0090112 - COPII vesicle uncoating

References:

GO:0090110 - COPII-coated vesicle cargo loading

References:

GO:0006886 - intracellular protein transport

References:

GO:0061709 - reticulophagy

References:

GO cellular component

GO:0030127 - COPII vesicle coat

References:

GO:0070971 - endoplasmic reticulum exit site

References:

GO molecular function

GO:0005096 - GTPase activator activity

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00626GelsolinGelsolin-like_domPfam
PF04810zf-Sec23_Sec24Znf_Sec23_Sec24Pfam
PF04811Sec23_trunkSec23/24_trunk_domPfam
PF04815Sec23_helicalSec23/24_helical_domPfam
PF08033Sec23_BSBeta-sandwich_Sec23_24Pfam
cd01478Sec23-likeCDD
cd11287Sec23_CSec23_CCDD
G3DSA:1.20.120.730:FF:000001CATH-FunFam
G3DSA:2.30.30.380:FF:000001CATH-FunFam
G3DSA:3.40.50.410:FF:000008CATH-FunFam
G3DSA:1.20.120.730CATH-Gene3D
G3DSA:2.30.30.380CATH-Gene3D
G3DSA:2.60.40.1670CATH-Gene3D
G3DSA:3.40.20.10ADF-H/Gelsolin-like_dom_sfCATH-Gene3D
G3DSA:3.40.50.410vWFA_dom_sfCATH-Gene3D
SSF53300vWFA_dom_sfSUPERFAMILY
SSF81811Sec23/24_helical_dom_sfSUPERFAMILY
SSF81995SUPERFAMILY
SSF82754Gelsolin-like_dom_sfSUPERFAMILY
SSF82919Znf_Sec23_Sec24_sfSUPERFAMILY
PTHR11141Sec23PANTHER

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25351951 - Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
Metodiev MD et al. J Med Genet 2014 Dec;51(12):834-8
PMID:27432890 - Sar1 localizes at the rims of COPII-coated membranes in vivo.
Kurokawa K et al. J Cell Sci 2016 Sep 01;129(17):3231-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs