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protein coding gene - hem15 (SPCC320.09) - ferrochelatase Hem15

Gene summary

Standard name
hem15
Systematic ID
SPCC320.09
Product
ferrochelatase Hem15
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59786
ORFeome ID
23/23A04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 148547..150734 reverse strand

Annotation

PBO:0005029 - 4.99.1.1

Disease association

MONDO:0001676 - erythropoietic protoporphyria

References:

MONDO:0019142 - inherited porphyria

References:

MONDO:0008319 - protoporphyria, erythropoietic, 1

References:

GO biological process

GO:0006783 - heme biosynthetic process

References:

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO molecular function

GO:0051537 - 2 iron, 2 sulfur cluster binding

References:

GO:0004325 - protoporphyrin ferrochelatase activity

References:

Modification

MOD:00739 - iron-sulfur cluster containing modification

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000741 - increased cellular pigment accumulation

References:

Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002427 - inviable spore with abnormal shape

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00762FerrochelataseFerrochelatasePFAM
cd00419Ferrochelatase_CFerrochelatase_CCDD
cd03411Ferrochelatase_NFerrochelatase_NCDD
PS00534FERROCHELATASEFerrochelatase_ASPROSITE_PATTERNS
G3DSA:3.40.50.1400:FF:000001FUNFAM
SSF53800ChelataseSUPERFAMILY
G3DSA:3.40.50.1400GENE3D
PTHR11108FERROCHELATASEFerrochelatasePANTHER
CoilCoilCOILS
MF_00323FerrochelataseFerrochelataseHAMAP
TIGR00109hemHFerrochelataseNCBIFAM

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:11948160 - Identification of [2Fe-2S] clusters in microbial ferrochelatases.
Dailey TA et al. J Bacteriol 2002 May;184(9):2460-4
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.
Lando D et al. PLoS One 2012;7(1):e29765
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24782769 - Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes.
Chiabrando D et al. Front Pharmacol 2014;5:61
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24929437 - The translational landscape of fission-yeast meiosis and sporulation.
Duncan CD et al. Nat Struct Mol Biol 2014 Jul;21(7):641-7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000003 - Disease Association Curation
PMID:38499131 - The deletion of ppr2 interferes iron sensing and leads to oxidative stress response in Schizosaccharomyces pombe.
Liu Z et al. Mitochondrion 2024 Mar 16;:101875