protein coding gene - ark1 (SPCC320.13c) - Aurora-B kinase Ark1

Gene summary

Standard name

ark1

Systematic ID

SPCC320.13c

Product

Aurora-B kinase Ark1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

aim1, SPCC330.16, SPCC320.12c

UniProt ID

O59790

ORFeome ID

18/18C05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 141630..143038 forward strand

Annotation

Protein features

Orthologs

• AURKB (HGNC:11390) Homo sapiens
• AURKC (HGNC:11391) Homo sapiens
• AURKA (HGNC:11393) Homo sapiens
• ark1 (SJAG_01837) Schizosaccharomyces japonicus
• IPL1 (YPL209C) Saccharomyces cerevisiae

References / Literature

PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.

Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98

PMID:28366744 - Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest.

May KM et al. Curr Biol 2017 Apr 24;27(8):1221-1228

PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.

Dey G et al. Nature 2020 Sep;585(7823):119-123

PMID:12426374 - Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.

Garcia MA et al. EMBO J 2002 Nov 15;21(22):6015-24

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:20929775 - Two histone marks establish the inner centromere and chromosome bi-orientation.

Yamagishi Y et al. Science 2010 Oct 08;330(6001):239-43

PMID:21965528 - Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.

Hálová L et al. J Cell Sci 2011 Oct 15;124(Pt 20):3441-9

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:21920317 - Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.

Sakuno T et al. Dev Cell 2011 Sep 13;21(3):534-45

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:34382912 - Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast.

Rezig IM et al. Cell Cycle 2021 Sep;20(18):1845-1860

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22521786 - Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.

Shepperd LA et al. Curr Biol 2012 May 22;22(10):891-9

PMID:29298360 - Chromosome passenger complex is required for the survival of cells with ring chromosomes in fission yeast.

Habib AGK et al. PLoS One 2018;13(1):e0190523

PMID:23438755 - A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation.

Kawashima SA et al. Chem Biol 2013 Feb 21;20(2):262-71

PMID:12676091 - S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response.

Petersen J et al. Curr Biol 2003 Apr 01;13(7):590-7

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:24583014 - Slow checkpoint activation kinetics as a safety device in anaphase.

Kamenz J et al. Curr Biol 2014 Mar 17;24(6):646-51

PMID:11861551 - Schizosaccharomyces pombe Bir1p, a nuclear protein that localizes to kinetochores and the spindle midzone, is essential for chromosome condensation and spindle elongation during mitosis.

Rajagopalan S et al. Genetics 2002 Feb;160(2):445-56

PMID:21664573 - Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.

Meadows JC et al. Dev Cell 2011 Jun 14;20(6):739-50

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:36108046 - Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.

Bai S et al. PLoS Genet 2022 Sep;18(9):e1010397

PMID:28825727 - Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.

Kakui Y et al. Nat Genet 2017 Oct;49(10):1553-1557

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25356547 - A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe.

Bhutta MS et al. PLoS One 2014;9(10):e111789

PMID:28178520 - Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

Meadows JC et al. Cell Rep 2017 Feb 07;18(6):1422-1433

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:19592249 - A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

Vanoosthuyse V et al. Curr Biol 2009 Jul 28;19(14):1176-81

PMID:19454013 - Conserved features of cohesin binding along fission yeast chromosomes.

Schmidt CK et al. Genome Biol 2009;10(5):R52

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17322402 - Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.

Kawashima SA et al. Genes Dev 2007 Feb 15;21(4):420-35

PMID:22281223 - Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.

Zich J et al. Curr Biol 2012 Feb 21;22(4):296-301

PMID:15525536 - The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.

Trautmann S et al. Dev Cell 2004 Nov;7(5):755-62

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:28343969 - Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.

Goto Y et al. Curr Biol 2017 Apr 03;27(7):1005-1012

PMID:22264609 - A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.

Choi SH et al. Curr Biol 2012 Feb 07;22(3):225-30

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29180432 - Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis.

Zhou X et al. Proc Natl Acad Sci U S A 2017 Dec 12;114(50):E10667-E10676

PMID:26900649 - The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.

Chmielewska AE et al. Cell Cycle 2016;15(5):740-7

PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.

Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807

PMID:22065639 - Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.

Chen JS et al. J Cell Biol 2011 Nov 14;195(4):583-93

PMID:22825872 - Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores.

Heinrich S et al. J Cell Sci 2012 Oct 15;125(Pt 20):4720-7

PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:20739936 - Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.

Tsukahara T et al. Nature 2010 Oct 07;467(7316):719-23

PMID:11554922 - Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair.

Morishita J et al. Genes Cells 2001 Sep;6(9):743-63

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11950927 - The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis.

Leverson JD et al. Mol Biol Cell 2002 Apr;13(4):1132-43

PMID:15195092 - Periodic gene expression program of the fission yeast cell cycle.

Rustici G et al. Nat Genet 2004 Aug;36(8):809-17

PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.

Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7

PMID:26696398 - Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast.

Matsuhara H et al. Genes Cells 2016 Jan;21(1):65-87

PMID:33176152 - Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast.

Gallardo P et al. Cell Rep 2020 Nov 10;33(6):108377

PMID:19570910 - A link between aurora kinase and Clp1/Cdc14 regulation uncovered by the identification of a fission yeast borealin-like protein.

Bohnert KA et al. Mol Biol Cell 2009 Aug;20(16):3646-59

PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502

PMID:25778919 - Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction.

Reyes C et al. J Cell Biol 2015 Mar 16;208(6):713-27

PMID:35293864 - Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B.

Lera-Ramirez M et al. Elife 2022 Mar 16;11

PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.

Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51

PMID:33529549 - Chiasmata and the kinetochore component Dam1 are crucial for elimination of erroneous chromosome attachments and centromere oscillation at meiosis I.

Wakiya M et al. Open Biol 2021 Feb;11(2):200308

PMID:11792803 - The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation.

Petersen J et al. J Cell Sci 2001 Dec;114(Pt 24):4371-84

PMID:15647375 - The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling.

Yamashita A et al. Mol Biol Cell 2005 Mar;16(3):1378-95

PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.

Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81

PMID:17301288 - Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.

Vanoosthuyse V et al. Mol Biol Cell 2007 May;18(5):1657-69