PomBase home

protein coding gene - tdk1 (SPCC330.04c) - single-gene toxin-antidote meiotic driver Tdk1

Gene summary

Standard name
tdk1
Systematic ID
SPCC330.04c
Product
single-gene toxin-antidote meiotic driver Tdk1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug135
UniProt ID
O74876
ORFeome ID
16/16F01
Characterisation status
meiotic driver
Feature type
mRNA gene
Genomic location
chromosome III: 112050..113431 reverse strand

Annotation

Comment

PBO:0017060 - biased repeat containing protein - 6 copies of 'WKKAREEDKAE' repeat and 6 copies of a smaller 'WRNSMDE' repeat

PBO:0114316 - repeat containing

GO biological process

GO:0110134 - meiotic drive

References:

GO cellular component

GO:0005654 - nucleoplasm

References:

GO:0005634 - nucleus

References:

Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0006790 - meiotic drive suppression

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001571 - increased protein-protein interaction

References:

Genotypes:

FYPO:0005116 - increased punctate nuclear protein localization

References:

Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

References:

Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0000579 - normal spore germination

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0003358 - sensitive to miconazole

References:

Genotypes:

Subunit composition

PBO:0015242 - homomeric(4)

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF08593Mug135_CMug135-like_CPFAM
CoilCoilCOILS

References / Literature

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39485795 - A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.
Hua Y et al. Proc Natl Acad Sci U S A 2024 Nov 05;121(45):e2408347121
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:39485800 - Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive.
Hua Y et al. Proc Natl Acad Sci U S A 2024 Nov 05;121(45):e2408618121
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623