protein coding gene - ura4 (SPCC330.05c) - orotidine 5'-phosphate decarboxylase Ura4

Gene summary

Standard name

ura4

Systematic ID

SPCC330.05c

Product

orotidine 5'-phosphate decarboxylase Ura4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P14965

ORFeome ID

10/10A08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 115589..116625 reverse strand

Annotation

Protein features

Orthologs

• UMPS (HGNC:12563) Homo sapiens
• ura4 (SJAG_03164) Schizosaccharomyces japonicus
• URA3 (YEL021W) Saccharomyces cerevisiae

References / Literature

PMID:14718525 - Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2004 Mar 26;279(13):12706-13

PMID:8493104 - Study of multiple fibrillarin mRNAs reveals that 3' end formation in Schizosaccharomyces pombe is sensitive to cold shock.

Girard JP et al. Nucleic Acids Res 1993 Apr 25;21(8):1881-7

PMID:11821054 - A DMSO-sensitive conditional mutant of the fission yeast orthologue of the Saccharomyces cerevisiae SEC13 gene is defective in septation.

Poloni D et al. FEBS Lett 2002 Jan 30;511(1-3):85-9

PMID:15546162 - pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.

Matsuyama A et al. Yeast 2004 Nov;21(15):1289-305

PMID:26536126 - Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.

Nishino K et al. PLoS One 2015;10(11):e0141796

PMID:17295836 - Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.

Kohda TA et al. Genes Cells 2007 Feb;12(2):155-70

PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

Weisman R et al. Genetics 2005 Feb;169(2):539-50

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:38415071 - The Cdc14 phosphatase, Clp1, does not affect genome expression.

Lopez Maury L et al. MicroPubl Biol 2024;2024

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:29784772 - A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.

Wang J et al. Mol Cell Biol 2018 Aug 01;38(15)

PMID:10487925 - Gene disruption in Schizosaccharomyces pombe using a temperature-sensitive Ura4p.

Davis K et al. Yeast 1999 Sep 15;15(12):1231-6

PMID:16115814 - Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M et al. Hum Mol Genet 2005 Oct 01;14(19):2851-8

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:32075773 - Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress.

Cabrera M et al. Cell Rep 2020 Feb 18;30(7):2430-2443.e4

PMID:38440330 - DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe .

Protacio RU et al. MicroPubl Biol 2024;2024

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:2834100 - Cloning and expression of the OMP decarboxylase gene URA4 from Schizosaccharomyces pombe.

Bach ML Curr Genet 1987;12(7):527-34

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:10233158 - Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Rupes I et al. Mol Biol Cell 1999 May;10(5):1495-510

PMID:22426534 - DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.

Sabouri N et al. Genes Dev 2012 Mar 15;26(6):581-93

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92

PMID:39945308 - Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast.

Oya T et al. FASEB J 2025 Feb 28;39(4):e70387

PMID:17248775 - Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Kohli J et al. Genetics 1977 Nov;87(3):471-89

PMID:27613427 - Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.

Maksimov V et al. Curr Genet 2017 May;63(2):343-357

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:22992726 - The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.

Takahashi H et al. J Biol Chem 2012 Nov 02;287(45):38158-67

PMID:23145069 - Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe.

Krzyzanowski MK et al. PLoS One 2012;7(11):e49059

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:37400983 - Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly.

Rahayu AF et al. J Biochem 2023 Sep 29;174(4):371-382

PMID:39527204 - Targeted Forward Genetics: Saturating Mutational Analyses of Specific Target Loci Within the Genome.

Protacio RU et al. Methods Mol Biol 2025;2862:223-239

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:6765174 - Expression of the cloned uracil permease gene of Saccharomyces cerevisiae in a heterologous membrane.

Chevallier MR et al. EMBO J 1982;1(3):375-7

PMID:8625425 - pH sensitivity of Schizosaccharomyces pombe: effect on the cellular phenotype associated with lacZ gene expression.

Arndt GM et al. Curr Genet 1996 Apr;29(5):457-61

PMID:12172965 - Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

Didmon M et al. Curr Genet 2002 Jul;41(4):241-53

PMID:12521309 - Post-transcriptional regulation of ura4+ gene expression by glucose in Schizosaccharomyces pombe.

Kim MJ et al. Mol Cells 2002 Dec 31;14(3):437-43

PMID:28345447 - Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants.

Nishino K et al. Biosci Biotechnol Biochem 2017 Jul;81(7):1444-1451

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23771057 - Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

Alper BJ et al. EMBO J 2013 Aug 28;32(17):2321-35

PMID:9211790 - Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle.

Benko Z et al. Curr Genet 1997 Jun;31(6):481-7

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23555823 - Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast.

Matsuo Y et al. PLoS One 2013;8(3):e59887

PMID:9339351 - Identification of the ure1+ gene encoding urease in fission yeast.

Tange Y et al. Curr Genet 1997 Sep;32(3):244-6

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:39132053 - Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles.

Protacio RU et al. MicroPubl Biol 2024;2024

PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.

Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54

PMID:9822592 - Localization of the 26S proteasome during mitosis and meiosis in fission yeast.

Wilkinson CR et al. EMBO J 1998 Nov 16;17(22):6465-76

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:3241625 - Observations on integrative transformation in Schizosaccharomyces pombe.

Grimm C et al. Mol Gen Genet 1988 Dec;215(1):87-93