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protein coding gene - alg11 (SPCC330.08) - GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase Alg11

Gene summary

Standard name
alg11
Systematic ID
SPCC330.08
Product
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase Alg11
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
gmd3
UniProt ID
O74878
ORFeome ID
44/44E07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 124266..127134 forward strand

Annotation

PBO:0000169 - 2.4.1.-

Complementation

PBO:0005014 - functionally complemented by S. cerevisiae ALG11

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Disease association

MONDO:0013349 - ALG11-congenital disorder of glycosylation

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MONDO:0015286 - congenital disorder of glycosylation

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MONDO:0005066 - metabolic disease

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GO biological process

GO:0006488 - dolichol-linked oligosaccharide biosynthetic process

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GO cellular component

GO:0098554 - cytoplasmic side of endoplasmic reticulum membrane

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GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO molecular function

GO:0004377 - GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003354 - decreased galactose level in glycoprotein glycan

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Genotypes:

FYPO:0004941 - decreased mannose level in glycoprotein glycan

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0001489 - inviable vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0004942 - normal galactose:mannose ratio in glycoprotein glycan

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Genotypes:

FYPO:0000961 - normal growth on sorbitol

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Genotypes:

FYPO:0000106 - sensitive to hygromycin B

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF15924ALG11_NALG11_NPFAM
PF00534Glycos_transf_1Glyco_trans_1PFAM
cd03806GT4_ALG11-likeALG11CDD
G3DSA:3.40.50.2000:FF:000168FUNFAM
SSF53756UDP-Glycosyltransferase/glycogen phosphorylaseSUPERFAMILY
G3DSA:3.40.50.2000Glycogen Phosphorylase B;GENE3D
PTHR45919GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASEALG11PANTHER

Orthologs

References / Literature

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:9878760 - The dolichol pathway of N-linked glycosylation.
Burda P et al. Biochim Biophys Acta 1999 Jan 06;1426(2):239-57
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11015724 - Schizosaccharomyces pombe gmd3(+)/alg11(+) is a functional homologue of Saccharomyces cerevisiae ALG11 which is involved in N-linked oligosaccharide synthesis.
Umeda K et al. Yeast 2000 Oct;16(14):1261-71