protein coding gene - mms2 (SPCC338.05c) - ubiquitin conjugating enzyme E2 Mms2

Gene summary

Standard name

mms2

Systematic ID

SPCC338.05c

Product

ubiquitin conjugating enzyme E2 Mms2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

spm2

UniProt ID

O74983

ORFeome ID

11/11D03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1366596..1367705 forward strand

Annotation

Protein features

Orthologs

• UBE2V1 (HGNC:12494) Homo sapiens
• UBE2V2 (HGNC:12495) Homo sapiens
• mms2 (SJAG_02918) Schizosaccharomyces japonicus
• MMS2 (YGL087C) Saccharomyces cerevisiae

References / Literature

PMID:34292936 - Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.

Su J et al. PLoS Genet 2021 Jul;17(7):e1009671

PMID:20176980 - Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Dolan WP et al. Genetics 2010 May;185(1):39-53

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:35011726 - Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase.

Kolesar P et al. Cells 2022 Jan 04;11(1)

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:22064477 - The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM et al. Mol Cell Biol 2012 Jan;32(2):276-87

PMID:35075549 - Schizosaccharomyces pombe Fzo1 is subjected to the ubiquitin-proteasome-mediated degradation during the stationary phase.

Ahmad F et al. Int Microbiol 2022 May;25(2):397-404

PMID:20453833 - Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast.

Coulon S et al. EMBO J 2010 Jun 16;29(12):2048-58

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063

PMID:41526646 - Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast.

Azadeh F et al. Sci Rep 2026 Jan 12;

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:17515930 - Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

Kai M et al. Nat Cell Biol 2007 Jun;9(6):691-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:12531016 - Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe.

Brown M et al. DNA Repair (Amst) 2002 Nov 03;1(11):869-80

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:16641370 - Postreplication repair and PCNA modification in Schizosaccharomyces pombe.

Frampton J et al. Mol Biol Cell 2006 Jul;17(7):2976-85

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

GO_REF:0000033 - Annotation inferences using phylogenetic trees