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protein coding gene - hsp20 (SPCC338.06c) - heat shock protein Hsp20/Hsp15.8

Gene summary

Standard name
hsp20
Systematic ID
SPCC338.06c
Product
heat shock protein Hsp20/Hsp15.8
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
Hsp15.8
UniProt ID
O74984
ORFeome ID
03/03D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1365118..1366139 forward strand

Annotation

Disease association

MONDO:0013411 - cataract 16 multiple types

References:

MONDO:0011413 - cataract 9 multiple types

References:

MONDO:0015626 - Charcot-Marie-Tooth disease

References:

MONDO:0011687 - Charcot-Marie-Tooth disease axonal type 2F

References:

MONDO:0012096 - Charcot-Marie-Tooth disease axonal type 2L

References:

MONDO:0014073 - dilated cardiomyopathy 1II

References:

MONDO:0013472 - fatal infantile hypertonic myofibrillar myopathy

References:

MONDO:0012130 - myofibrillar myopathy 2

References:

MONDO:0976133 - myopathy, myofibrillar, 13, with rimmed vacuoles

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MONDO:0005071 - nervous system disorder

References:

MONDO:0008025 - neuronopathy, distal hereditary motor, type 2A

References:

MONDO:0012080 - neuronopathy, distal hereditary motor, type 2B

References:

MONDO:0013243 - neuronopathy, distal hereditary motor, type 2C

References:

GO biological process

GO:0006457 - protein folding

References:

GO cellular component

GO:0005739 - mitochondrion

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GO molecular function

GO:0044183 - protein folding chaperone

References:

Miscellaneous functional group

PBO:0000255 - chaperone

Modification

MOD:00046 - O-phospho-L-serine

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00011HSP20A-crystallin/Hsp20_domPfam
cd06464ACD_sHsps-likeCDD
PS01031SHSPA-crystallin/Hsp20_domPROSITE profiles
G3DSA:2.60.40.790:FF:000065CATH-FunFam
G3DSA:2.60.40.790HSP20-like_chaperoneCATH-Gene3D
SSF49764HSP20-like_chaperoneSUPERFAMILY
PTHR11527Small_HSPPANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23293578 - Molecular genetics of charcot-marie-tooth disease: from genes to genomes.
Azzedine H et al. Mol Syndromol 2012 Nov;3(5):204-14
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18543332 - Characterization of a sHsp of Schizosaccharomyces pombe, SpHsp15.8, and the implication of its functional mechanism by comparison with another sHsp, SpHsp16.0.
Sugino C et al. Proteins 2009 Jan;74(1):6-17
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399