PomBase home

protein coding gene - naa15 (SPCC338.07c) - NatA N-acetyltransferase complex regulatory subunit Naa15

Gene summary

Standard name
naa15
Systematic ID
SPCC338.07c
Product
NatA N-acetyltransferase complex regulatory subunit Naa15
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74985
ORFeome ID
28/28A07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1362618..1364953 forward strand

Annotation

Disease association

MONDO:0030916 - intellectual disability, autosomal dominant 50

References:

GO biological process

GO:0051604 - protein maturation

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0031415 - NatA complex

References:

GO molecular function

GO:0010698 - acetyltransferase activator activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111755 - TPR repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0002667 - decreased peptide-serine-N-acetyltransferase activity

References:

Genotypes:

FYPO:0002668 - normal peptide-serine-N-acetyltransferase activity

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12569NatA_aux_suNatA_aux_suPfam
SM00028TPRTPR_rptSMART
G3DSA:1.25.40.1010:FF:000005CATH-FunFam
G3DSA:1.25.40.1040:FF:000003CATH-FunFam
G3DSA:1.25.40.1010CATH-Gene3D
G3DSA:1.25.40.1040CATH-Gene3D
SSF48452TPR-like_helical_dom_sfSUPERFAMILY
PTHR22767PANTHER
PIRSF000422N-terminal-AcTrfase-A_aux_suNatA_aux_suPIRSF
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23912279 - Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.
Liszczak G et al. Nat Struct Mol Biol 2013 Sep;20(9):1098-105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:41526646 - Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast.
Azadeh F et al. Sci Rep 2026 Jan 12;
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323