protein coding gene - mto1 (SPCC417.07c) - gamma tubulin complex linker Mto1

Gene summary

Standard name

mto1

Systematic ID

SPCC417.07c

Product

gamma tubulin complex linker Mto1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

mbo1, mod20

UniProt ID

O94488

ORFeome ID

30/30D06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 1679761..1683271 reverse strand

Annotation

Protein features

Orthologs

• PDE4DIP (HGNC:15580) Homo sapiens
• CDK5RAP2 (HGNC:18672) Homo sapiens
• mto1 (SJAG_02737) Schizosaccharomyces japonicus
• SPC72 (YAL047C) Saccharomyces cerevisiae

References / Literature

PMID:21215368 - The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.

Braun S et al. Cell 2011 Jan 07;144(1):41-54

PMID:15800064 - Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring.

Venkatram S et al. Mol Biol Cell 2005 Jun;16(6):3052-63

PB_REF:0000003 - Disease Association Curation

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:28619713 - Molecular model of fission yeast centrosome assembly determined by superresolution imaging.

Bestul AJ et al. J Cell Biol 2017 Aug 07;216(8):2409-2424

PMID:17881496 - The Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast.

Franco A et al. J Cell Sci 2007 Oct 01;120(Pt 19):3345-51

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:30427751 - The J-domain cochaperone Rsp1 interacts with Mto1 to organize noncentrosomal microtubule assembly.

Shen J et al. Mol Biol Cell 2019 Jan 15;30(2):256-267

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:37099380 - Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.

Bellingham-Johnstun K et al. Mol Biol Cell 2023 Jul 01;34(8):ar77

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:36980258 - Actin-Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast.

Bellingham-Johnstun K et al. Cells 2023 Mar 16;12(6)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.

Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26243668 - Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis.

Borek WE et al. Nat Commun 2015 Aug 05;6:7929

PMID:24196444 - Mal3, the Schizosaccharomyces pombe homolog of EB1, is required for karyogamy and for promoting oscillatory nuclear movement during meiosis.

Polakova S et al. Cell Cycle 2014;13(1):72-7

PMID:31483748 - Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.

Zhurinsky J et al. Mol Biol Cell 2019 Oct 01;30(21):2695-2708

PMID:23755176 - Proper microtubule structure is vital for timely progression through meiosis in fission yeast.

Yamashita A et al. PLoS One 2013;8(6):e65082

PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:18562692 - Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability.

Meadows JC et al. Mol Biol Cell 2008 Sep;19(9):3713-23

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:15772152 - Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.

Zimmerman S et al. Mol Biol Cell 2005 Jun;16(6):2719-33

PMID:27611693 - A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.

Katsumata K et al. PLoS Genet 2016 Sep;12(9):e1006304

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:15120067 - Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p.

Sawin KE et al. Curr Biol 2004 May 04;14(9):763-75

PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113

PMID:15659644 - Fission yeast mto2p regulates microtubule nucleation by the centrosomin-related protein mto1p.

Samejima I et al. Mol Biol Cell 2005 Jun;16(6):3040-51

PMID:15004232 - Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function.

Venkatram S et al. Mol Biol Cell 2004 May;15(5):2287-301

PMID:24943839 - A role for nuclear envelope-bridging complexes in homology-directed repair.

Swartz RK et al. Mol Biol Cell 2014 Aug 15;25(16):2461-71

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.

Hanna SM et al. G3 (Bethesda) 2024 Oct 29;

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63

PMID:38442865 - The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle.

Kume K et al. Open Biol 2024 Mar;14(3):230440

PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.

Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:21444751 - Microtubule stabilization in vivo by nucleation-incompetent γ-tubulin complex.

Anders A et al. J Cell Sci 2011 Apr 15;124(Pt 8):1207-13

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:19001497 - Two distinct regions of Mto1 are required for normal microtubule nucleation and efficient association with the gamma-tubulin complex in vivo.

Samejima I et al. J Cell Sci 2008 Dec 01;121(Pt 23):3971-80

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

Pfam:PF07989 - Unknown title

PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.

Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308

PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.

Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:20970338 - Fission yeast Mto1 regulates diversity of cytoplasmic microtubule organizing centers.

Samejima I et al. Curr Biol 2010 Nov 09;20(21):1959-65

PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.

Abenza JF et al. PLoS One 2014;9(9):e106959

PMID:29779879 - The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast.

Flor-Parra I et al. Curr Biol 2018 Jun 04;28(11):1681-1691.e4

PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .

Guydosh NR et al. Elife 2017 Sep 25;6

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:16111942 - Hrs1p/Mcp6p on the meiotic SPB organizes astral microtubule arrays for oscillatory nuclear movement.

Tanaka K et al. Curr Biol 2005 Aug 23;15(16):1479-86

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:29958883 - Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast.

Kume K et al. Biochem Biophys Res Commun 2018 Sep 05;503(2):1160-1167

PMID:18061564 - Stabilization of overlapping microtubules by fission yeast CLASP.

Bratman SV et al. Dev Cell 2007 Dec;13(6):812-27

PMID:24704079 - Activation of the γ-tubulin complex by the Mto1/2 complex.

Lynch EM et al. Curr Biol 2014 Apr 14;24(8):896-903

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183