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protein coding gene - dal51 (SPCC417.10) - allantoate transporter family Dal51

Gene summary

Standard name
dal51
Systematic ID
SPCC417.10
Product
allantoate transporter family Dal51
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
dal5h1
UniProt ID
O94491
ORFeome ID
24/24G09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1695516..1697592 forward strand

Annotation

Disease association

MONDO:0011568 - autosomal dominant nonsyndromic hearing loss 25

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MONDO:0010027 - free sialic acid storage disease, infantile form

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MONDO:0002561 - lysosomal storage disease

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MONDO:0005066 - metabolic disease

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MONDO:0011449 - Salla disease

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MONDO:0010028 - sialuria

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GO biological process

GO:0055085 - transmembrane transport

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GO cellular component

GO:0032153 - cell division site

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GO:0051286 - cell tip

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GO:0005783 - endoplasmic reticulum

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GO:0005794 - Golgi apparatus

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GO:0016020 - membrane

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GO molecular function

GO:0022857 - transmembrane transporter activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF07690MFS_1MFSPfam
cd17327MFS_FEN2_likeCDD
G3DSA:1.20.1250.20:FF:000064CATH-FunFam
G3DSA:1.20.1250.20MFS_trans_sfCATH-Gene3D
SSF103473MFS_trans_sfSUPERFAMILY
PTHR43791PANTHER
TIGR008932A0114NCBIFAM
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PB_REF:0000003 - Disease Association Curation
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.
Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623