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protein coding gene - nte1 (SPCC4B3.04c) - lysophospholipase

Gene summary

Standard name
nte1
Systematic ID
SPCC4B3.04c
Product
lysophospholipase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USJ4
ORFeome ID
30/30F02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1168542..1173299 forward strand

Annotation

Disease association

MONDO:0008980 - ataxia-hypogonadism-choroidal dystrophy syndrome

References:

MONDO:0012787 - hereditary spastic paraplegia 39

References:

MONDO:0009514 - Laurence-Moon syndrome

References:

MONDO:0010152 - trichomegaly-retina pigmentary degeneration-dwarfism syndrome

References:

GO biological process

GO:0034638 - phosphatidylcholine catabolic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO molecular function

GO:0004622 - phosphatidylcholine lysophospholipase A1 activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00027cNMP_bindingcNMP-bd_domPfam
PF01734PatatinPNPLA_domPfam
PF24179NTE_PloopNTE1_P-loop_domPfam
cd00038CAP_EDcNMP-bd_domCDD
cd07227Pat_Fungal_NTE1CDD
PS00888CNMP_BINDING_1cNMP-bd_CSPROSITE patterns
PS50042CNMP_BINDING_3cNMP-bd_domPROSITE profiles
PS51635PNPLAPNPLA_domPROSITE profiles
SM00100cNMPcNMP-bd_domSMART
G3DSA:2.60.120.10:FF:000086CATH-FunFam
G3DSA:3.40.1090.10:FF:000007CATH-FunFam
G3DSA:2.60.120.10RmlC-like_jellyrollCATH-Gene3D
G3DSA:3.40.1090.10CATH-Gene3D
SSF51206cNMP-bd_dom_sfSUPERFAMILY
SSF52151Acyl_Trfase/lysoPLipaseSUPERFAMILY
PTHR14226NTEPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7