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protein coding gene - hem12 (SPCC4B3.05c) - uroporphyrinogen decarboxylase Hem12

Gene summary

Standard name
hem12
Systematic ID
SPCC4B3.05c
Product
uroporphyrinogen decarboxylase Hem12
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USJ5
ORFeome ID
44/44B02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1166501..1168277 forward strand

Annotation

PBO:0005402 - 4.1.1.37

Disease association

MONDO:0008296 - familial porphyria cutanea tarda

References:

MONDO:0019142 - inherited porphyria

References:

MONDO:0015104 - porphyria cutanea tarda

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GO biological process

GO:0006783 - heme biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0004853 - uroporphyrinogen decarboxylase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

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Genotypes:

FYPO:0007188 - normal growth on sampangine

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002767 - resistance to terbinafine

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

Protein features

IDNameInterPro nameDB name
PF01208URO-DUroporphyrinogen_deCOasePfam
cd00717URO-DUroporphyrinogen_deCO2ase_HemECDD
PS00906UROD_1Uroporphyrinogen_deCOasePROSITE patterns
PS00907UROD_2Uroporphyrinogen_deCOasePROSITE patterns
G3DSA:3.20.20.210:FF:000004CATH-FunFam
G3DSA:3.20.20.210UROD/MetE-like_sfCATH-Gene3D
SSF51726UROD/MetE-like_sfSUPERFAMILY
PTHR21091PANTHER
TIGR01464hemEUroporphyrinogen_deCO2ase_HemENCBIFAM
MF_00218URO_DUroporphyrinogen_deCO2ase_HemEHAMAP

Orthologs

References / Literature

PMID:28377506 - Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.
Singh A et al. J Biol Chem 2017 Jun 02;292(22):9088-9103
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000003 - Disease Association Curation
PMID:24782769 - Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes.
Chiabrando D et al. Front Pharmacol 2014;5:61
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623