protein coding gene - mrpl12 (SPCC4B3.09c) - mitochondrial ribosomal protein subunit L12

Gene summary

Standard name: mrpl12
Systematic ID: SPCC4B3.09c
Product: mitochondrial ribosomal protein subunit L12
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9USJ9
ORFeome ID: 07/07F11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome III: 1160456..1162316 forward strand

Annotation

Disease association

MONDO:0033533 - combined oxidative phosphorylation deficiency 45

References:

PB_REF:0000006

GO biological process

GO:0032543 - mitochondrial translation

References:

GO_REF:0000050

GO cellular component

GO:0005762 - mitochondrial large ribosomal subunit

References:

GO_REF:0000033

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0003729 - mRNA binding

References:

GO_REF:0000033

GO:0003735 - structural constituent of ribosome

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

mrpl12delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

mrpl12delta

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

mrpl12delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF16320	Ribosomal_L12_N	Ribosomal_bL12_oligo	PFAM
PF00542	Ribosomal_L12	Ribosomal_bL12_C	PFAM
cd00387	Ribosomal_L7_L12	Ribosomal_bL12	CDD
G3DSA:3.30.1390.10:FF:000001			FUNFAM
SSF48300	Ribosomal protein L7/12, oligomerisation (N-terminal) domain	Ribosomal_bL12_oligo_N_sf	SUPERFAMILY
SSF54736	ClpS-like	Ribosomal_bL12_C/ClpS-like	SUPERFAMILY
G3DSA:1.20.5.710	Single helix bin	Ribosomal_bL12_oligo_N_sf	GENE3D
G3DSA:3.30.1390.10		Ribosomal_bL12_C/ClpS-like	GENE3D
PTHR45987	39S RIBOSOMAL PROTEIN L12	Ribosomal_bL12	PANTHER
Coil	Coil		COILS
MF_00368	Ribosomal_bL12	Ribosomal_bL12	HAMAP

Orthologs

MRPL12 (HGNC:10378) Homo sapiens
mrpl12 (SJAG_05218) Schizosaccharomyces japonicus
MNP1 (YGL068W) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6