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protein coding gene - fra3 (SPCC4B3.11c) - mitochondrial [4Fe-4S] cluster transfer protein Fra3

Gene summary

Standard name
fra3
Systematic ID
SPCC4B3.11c
Product
mitochondrial [4Fe-4S] cluster transfer protein Fra3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
aim1
UniProt ID
Q9USK1
ORFeome ID
02/02C05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1156091..1156556 forward strand

Annotation

Disease association

MONDO:0011612 - glycine encephalopathy

References:

MONDO:0004069 - inborn mitochondrial metabolism disorder

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MONDO:0013675 - multiple mitochondrial dysfunctions syndrome 2

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MONDO:0005071 - nervous system disorder

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GO biological process

GO:0051604 - protein maturation

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GO cellular component

GO:0005759 - mitochondrial matrix

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GO:0005739 - mitochondrion

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Multi-locus phenotype

FYPO:0005639 - normal RNA level during cellular response to iron ion starvation

References:

Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0005639 - normal RNA level during cellular response to iron ion starvation

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FYPO:0000763 - resistance to cadmium

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FYPO:0000764 - resistance to cycloheximide

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FYPO:0009038 - resistance to egtazic acid

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FYPO:0009035 - resistance to formamide

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FYPO:0001103 - resistance to hydrogen peroxide

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FYPO:0001583 - resistance to lithium

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FYPO:0007808 - resistance to valproic acid

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FYPO:0000830 - resistance to vanadate

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FYPO:0007933 - sensitive to 2,2′-dipyridyl

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FYPO:0001097 - sensitive to amitrole

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FYPO:0009067 - sensitive to amorolfine

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FYPO:0000799 - sensitive to diamide

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FYPO:0009071 - sensitive to itraconazole

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FYPO:0002328 - sensitive to terbinafine

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FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01722BolABolAPFAM
SSF82657BolA-likeBolA-like_sfSUPERFAMILY
G3DSA:3.30.300.90BolA-like_sfGENE3D
PTHR46188BOLA-LIKE PROTEIN 3Mt_Fe-S_assembly_factorPANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24334290 - Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5.
Baker PR et al. Brain 2014 Feb;137(Pt 2):366-79
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24897379 - Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation.
Jacques JF et al. PLoS One 2014;9(6):e98959
PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.
Nishida I et al. J Biol Chem 2023 Jun;299(6):104797
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480