protein coding gene - mid1 (SPCC4B3.15) - anillin-related medial ring protein Mid1
Gene summary
- Standard name
- mid1
- Systematic ID
- SPCC4B3.15
- Product
- anillin-related medial ring protein Mid1
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- Synonyms
- dmf1
- UniProt ID
- P78953
- ORFeome ID
- 47/47B12
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome III: 1147316..1150435 reverse strand
Annotation
Multi-locus phenotype
References:
Genotypes:
- mid1-3A(M616A,L618A,P619A aa) mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa) mid1-helix*(F683A,F684A,L687A,F688A aa)
References:
Genotypes:
- cdr2-2A(S476A,S632A aa) mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- cdr2delta mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- cdr2delta mid1delta
- mid1delta rtn1delta tts1delta yop1delta
References:
Genotypes:
- blt1delta mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- cdc16-116(R105C aa) mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- gef2delta mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
References:
Genotypes:
- cdc15-22D(S405D,T419D,T492D,S511D,S527D,S605D,S636D,S702D,S710D,S721D,S732D,S743D,S752D,S774D,S785D,S786D,S813D,S821D,S831D,S836D,S840D aa) fic1delta mid1delta pom1-as1(T778G aa)
- cdc15-22D(S405D,T419D,T492D,S511D,S527D,S605D,S636D,S702D,S710D,S721D,S732D,S743D,S752D,S774D,S785D,S786D,S813D,S821D,S831D,S836D,S840D aa) mid1delta pom1-as1(T778G aa)
- cdc15-22D(S405D,T419D,T492D,S511D,S527D,S605D,S636D,S702D,S710D,S721D,S732D,S743D,S752D,S774D,S785D,S786D,S813D,S821D,S831D,S836D,S840D aa) mid1delta pom1-as1(T778G aa) pxl1delta
- kin1-as1(F220G aa) mid1delta
- mid1delta pck1-as2(M744G aa)
- mid1delta pom1-as1(T778G aa)
- mid1delta shk1-as2(M460A aa)
References:
Genotypes:
- cdr1delta mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
- cdr2delta mid1-9A(S110A,S127A,S218A,S227A,S329A,S432A,S452A,S464A,S531A aa)
Qualitative gene expression
Quantitative gene expression
Single locus phenotype
References:
Genotypes:
- mid1-366(G718D aa)
- mid1-nsm-6Ala(450-506,S15A,S24A,T34A,S46A,S62A,S95A,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1-nsm-delta50-100(50-100,450-506,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1delta
References:
Genotypes:
- mid1-(1-100)-(401-800)(101-400,801-920 Δaa)
- mid1-(1-580)(581-920 Δaa)[Overexpression]
- mid1-(1-800)(801-920 Δaa)
- mid1-6Ala(S15A,S24A,T34A,S46A,S62A,S95A aa)
- mid1-helix*(F683A,F684A,L687A,F688A aa)[Overexpression]
- mid1-helix*-NLS*(F683A,F684A,L687A,F688A,R691Q,K692N,K693S,R694Q,K695S aa)[Overexpression]
- mid1delta
References:
Genotypes:
- mid1-3A(M616A,L618A,P619A aa)
- mid1-helix*-NLS*-Cter(1-506,F683A,F684A,L687A,F688A,R691Q,K692N,K693S,R694Q,K695S aa)[Overexpression]
References:
Genotypes:
- mid1+(wild type)[Overexpression]
- mid1-(1-100)-(401-580)(101-400,581-920 Δaa)[Overexpression]
- mid1-(1-100)-(401-680)(101-400,681-920 Δaa)[Knockdown]
- mid1-(1-100)(101-920 Δaa)[Overexpression]
- mid1-(1-200)(201-920 Δaa)[Overexpression]
- mid1-(1-40)-(101-920)(41-100 Δaa)
- mid1-(1-420)(421-920 Δaa)[Overexpression]
- mid1-(1-506)(507-920 Δaa)
- mid1-(1-580)(581-920 Δaa)[Overexpression]
- mid1-(101-920)(1-100 Δaa)[Overexpression]
- mid1-(581-920)(1-580 Δaa)[Knockdown]
- mid1-(681-920)(1-680 Δaa)
- mid1-(801-920)(1-800 Δaa)
- mid1-18(S873F aa)
- mid1-NLS*-Cter(1-506,R691Q,K692N,K693S,R694Q,K695S aa)[Overexpression]
- mid1-delta1-150(aa)
- mid1-delta1-507(aa)[Overexpression]
- mid1-helix*-Cter(1-506,F683A,F684A,L687A,F688A aa)[Overexpression]
- mid1-helix*(F683A,F684A,L687A,F688A aa)[Overexpression]
- mid1-helix*-NLS*-Cter(1-506,F683A,F684A,L687A,F688A,R691Q,K692N,K693S,R694Q,K695S aa)[Overexpression]
- mid1-helix*-NLS*(F683A,F684A,L687A,F688A,R691Q,K692N,K693S,R694Q,K695S aa)[Overexpression]
- mid1-nsm(450-506,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1-nsm-6Ala(450-506,S15A,S24A,T34A,S46A,S62A,S95A,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1-nsm-6AlaT517A(450-506,S15A,S24A,T34A,S46A,S62A,S95A,T517A,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1-nsm-8Ala(450-506,S15A,S24A,T34A,S46A,S42A,S62A,S67A,S95A,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1-nsm-delta50-100(50-100,450-506,R691Q,K692N,K693S,R694Q,K695S aa)
- mid1delta
Protein features
| ID | Name | InterPro name | DB name |
| cd00821 | PH | | CDD |
| PS50003 | PH_DOMAIN | PH_domain | PROSITE_PROFILES |
| SM00233 | PH_update | PH_domain | SMART |
| SSF50729 | PH domain-like | | SUPERFAMILY |
| G3DSA:2.30.29.30 | | PH-like_dom_sf | GENE3D |
| mobidb-lite-Disorder | disorder_prediction | | MOBIDB-Disorder |
| mobidb-lite-Polar | disorder_prediction | | MOBIDB-Polar |
Orthologs
- ANLN (HGNC:14082) Homo sapiens
- mid1 (SJAG_01143) Schizosaccharomyces japonicus
- BUD4 (YJR092W) Saccharomyces cerevisiae
References / Literature
- PMID:23615450 - Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.
- Tebbs IR et al. Mol Biol Cell 2013 Jun;24(12):1904-17
- PMID:40161431 - Characterization of temperature-sensitive alleles of anillin-like Mid1 and polo kinase Plo1 in Schizosaccharomyces pombe .
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- PMID:21376595 - IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast.
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- Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70
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- PMID:34382912 - Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast.
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- PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.
- Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60
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- Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75
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- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
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- Sohrmann M et al. Genes Dev 1996 Nov 01;10(21):2707-19
- PMID:22918943 - Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.
- Saha S et al. Mol Biol Cell 2012 Oct;23(20):3982-92
- PMID:15184401 - Myosin-II reorganization during mitosis is controlled temporally by its dephosphorylation and spatially by Mid1 in fission yeast.
- Motegi F et al. J Cell Biol 2004 Jun 07;165(5):685-95
- PMID:12615979 - Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase.
- Reynolds N et al. J Cell Sci 2003 Apr 01;116(Pt 7):1377-87
- PMID:12668659 - An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation.
- Tasto JJ et al. J Cell Biol 2003 Mar 31;160(7):1093-103
- PMID:34958661 - Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
- Opalko HE et al. J Cell Biol 2022 Feb 07;221(2)
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- Hercyk BS et al. Genetics 2019 Dec;213(4):1341-1356
- PMID:19075108 - Assembly of normal actomyosin rings in the absence of Mid1p and cortical nodes in fission yeast.
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- PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.
- Pardo M et al. Science 2003 Jun 06;300(5625):1569-74
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- Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
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- PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.
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- PMID:12411492 - Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.
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- PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
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- PMID:8834798 - Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring.
- Chang F et al. J Cell Sci 1996 Jan;109 ( Pt 1):131-42
- PMID:19427212 - Spatial control of cytokinesis by Cdr2 kinase and Mid1/anillin nuclear export.
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- Liu Y et al. Mol Biol Cell 2016 Aug 15;27(16):2528-41
- PMID:28784611 - Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis.
- Snider CE et al. J Cell Biol 2017 Oct 02;216(10):3041-3050
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- Paoletti A et al. Mol Biol Cell 2000 Aug;11(8):2757-73
- PMID:15385632 - Requirements of fission yeast septins for complex formation, localization, and function.
- An H et al. Mol Biol Cell 2004 Dec;15(12):5551-64
- PMID:24115772 - SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
- Bohnert KA et al. Genes Dev 2013 Oct 01;27(19):2164-77
- PMID:18256290 - Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
- Pinar M et al. Mol Biol Cell 2008 Apr;19(4):1727-38
- PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
- Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
- PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
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- Lee IJ et al. J Cell Sci 2012 Jun 15;125(Pt 12):2973-85
- PMID:15857958 - Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
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- PMID:33496728 - Molecular organization of cytokinesis node predicts the constriction rate of the contractile ring.
- Bellingham-Johnstun K et al. J Cell Biol 2021 Mar 01;220(3)
- PMID:18378776 - The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.
- Clifford DM et al. J Cell Biol 2008 Apr 07;181(1):79-88
- PMID:25866389 - Rewiring of cellular division site selection in evolution of fission yeasts.
- Gu Y et al. Curr Biol 2015 May 04;25(9):1187-94
- PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
- Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
- PMID:18257517 - Phosphoproteome analysis of fission yeast.
- Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
- PMID:25959226 - Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1.
- Sun L et al. Dev Cell 2015 May 26;33(4):413-26
- PMID:36426865 - The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells.
- Rezig IM et al. Cell Cycle 2023;22(6):633-644
- PMID:22298427 - Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.
- Ye Y et al. Mol Biol Cell 2012 Apr;23(7):1181-95
- PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
- Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
- PMID:12654901 - Mid2p stabilizes septin rings during cytokinesis in fission yeast.
- Berlin A et al. J Cell Biol 2003 Mar 31;160(7):1083-92
- PMID:22918954 - Characterization of structural and functional domains of the anillin-related protein Mid1p that contribute to cytokinesis in fission yeast.
- Saha S et al. Mol Biol Cell 2012 Oct;23(20):3993-4007
- PMID:26071525 - Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.
- Guzmán-Vendrell M et al. J Cell Sci 2015 Aug 01;128(15):2842-53
- PMID:29343550 - Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
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