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protein coding gene - rec11 (SPCC4E9.01c) - meiotic cohesin complex STAG protein Rec11

Gene summary

Standard name
rec11
Systematic ID
SPCC4E9.01c
Product
meiotic cohesin complex STAG protein Rec11
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCC550.16c
UniProt ID
Q92380
ORFeome ID
48/48B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1223308..1226968 reverse strand

Annotation

Comment

PBO:0004107 - region specific activator of recombination

References:

Disease association

MONDO:0026763 - holoprosencephaly 13, X-linked

References:

MONDO:0030912 - intellectual disability, autosomal dominant 47

References:

MONDO:0026722 - Mullegama-Klein-Martinez syndrome

References:

MONDO:0014321 - premature ovarian failure 8

References:

MONDO:0030507 - spermatogenic failure 61

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GO biological process

GO:0031619 - homologous chromosome orientation in meiotic metaphase I

References:

GO:0030999 - linear element assembly

References:

GO:0010789 - meiosis I sister chromatid cohesion

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GO:0051177 - meiotic sister chromatid cohesion

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GO cellular component

GO:0000785 - chromatin

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GO:0000793 - condensed chromosome

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GO:0030893 - meiotic cohesin complex

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GO:0005634 - nucleus

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GO molecular function

GO:0061776 - ATP-dependent topological DNA co-entrapment activity

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GO:0003682 - chromatin binding

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0004077 - abnormal sporulation resulting in formation of ascus with single large spore

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Genotypes:

FYPO:0003378 - abolished meiosis I

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Genotypes:

FYPO:0003379 - abolished meiosis II

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Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0002093 - decreased meiotic sister chromatid cohesion

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

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Genotypes:

FYPO:0005865 - normal histone H3-K9 methylation at silent mating-type cassette during vegetative growth

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Genotypes:

FYPO:0003182 - sister chromatid nondisjunction at meiosis II

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Genotypes:

Protein features

PBO:0111765 - HEAT repeat

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004585 - abnormal linear element morphology

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0003564 - abnormal meiotic DNA double-strand break formation

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Genotypes:

FYPO:0003181 - abolished meiotic DNA double-strand break formation

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0002093 - decreased meiotic sister chromatid cohesion

References:

Genotypes:

FYPO:0004666 - decreased meiotic sister chromatid cohesion along chromosome arms

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Genotypes:

FYPO:0005576 - decreased protein localization to chromatin during meiotic cell cycle

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Genotypes:

FYPO:0005577 - decreased protein phosphorylation during meiotic cell cycle

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0005986 - linear elements present in decreased numbers

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0002219 - normal chromosome disjunction at meiosis I

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0003835 - normal horsetail movement

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Genotypes:

FYPO:0003562 - normal horsetail nucleus morphology

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Genotypes:

FYPO:0000488 - normal meiotic recombination

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Genotypes:

FYPO:0004667 - normal meiotic sister chromatid cohesion at centromere

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Genotypes:

FYPO:0003178 - normal meiotic sister chromatid segregation

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0000084 - sensitive to 6-azauracil

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005633 - sister kinetochore dissociation in meiotic metaphase I, normal chromosome segregation in meiosis I, and sister chromatid non-disjunction in meiosis II

References:

Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

Protein features

IDNameInterPro nameDB name
PF08514STAGSTAGPfam
PF21581SCDSCDPfam
PF24571HEAT_SCC3-SAHEAT_SCC3-SAPfam
PS51425SCDSCDPROSITE profiles
G3DSA:1.25.10.10ARM-likeCATH-Gene3D
SSF48371ARM-type_foldSUPERFAMILY
PTHR11199Cohesin_Scc3/SAPANTHER

Orthologs

References / Literature

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:16043696 - Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.
Ellermeier C et al. Proc Natl Acad Sci U S A 2005 Aug 02;102(31):10952-7
PMID:21920317 - Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.
Sakuno T et al. Dev Cell 2011 Sep 13;21(3):534-45
PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641
PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.
Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71
PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).
Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70
PMID:14972679 - Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.
Rabitsch KP et al. Curr Biol 2004 Feb 17;14(4):287-301
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.
Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:8299939 - Region-specific activators of meiotic recombination in Schizosaccharomyces pombe.
DeVeaux LC et al. Genes Dev 1994 Jan;8(2):203-10
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:14532136 - Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast.
Kitajima TS et al. EMBO J 2003 Oct 15;22(20):5643-53
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:9076725 - Region-specific meiotic recombination in Schizosaccharomyces pombe: the rec11 gene.
Li YF et al. Mol Microbiol 1997 Mar;23(5):869-78
PMID:30078721 - Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers.
Nambiar M et al. Mol Cell 2018 Aug 16;71(4):540-553.e4
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:12665553 - Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.
Molnar M et al. J Cell Sci 2003 May 01;116(Pt 9):1719-31
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15226405 - S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.
Lorenz A et al. J Cell Sci 2004 Jul 01;117(Pt 15):3343-51
PMID:23395004 - Protein determinants of meiotic DNA break hot spots.
Fowler KR et al. Mol Cell 2013 Mar 07;49(5):983-96
PMID:18780734 - Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe.
Doll E et al. Genetics 2008 Oct;180(2):727-40
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:12750522 - Distinct cohesin complexes organize meiotic chromosome domains.
Kitajima TS et al. Science 2003 May 16;300(5622):1152-5
PMID:20404563 - High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.
Rumpf C et al. Cell Cycle 2010 May;9(9):1802-8
PMID:16360688 - Control of Shugoshin function during fission-yeast meiosis.
Vaur S et al. Curr Biol 2005 Dec 20;15(24):2263-70
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:26173815 - Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.
Zhou H et al. Yeast 2015 Oct;32(10):643-55
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .
Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.
Folco HD et al. Genetics 2019 Sep;213(1):127-141
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.
Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225