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protein coding gene - cig1 (SPCC4E9.02) - G1/S-specific B-type cyclin Cig1

Gene summary

Standard name
cig1
Systematic ID
SPCC4E9.02
Product
G1/S-specific B-type cyclin Cig1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPCC645.01
UniProt ID
P24865
ORFeome ID
19/19H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome III: 1227226..1229303 forward strand

Annotation

Complementation

PBO:0012861 - does not functionally complement S. cerevisiae CLN1/2/3

References:

GO biological process

GO:1900087 - positive regulation of G1/S transition of mitotic cell cycle

References:

GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process

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GO:2000045 - regulation of G1/S transition of mitotic cell cycle

References:

GO:0010520 - regulation of reciprocal meiotic recombination

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GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

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GO:0005737 - cytoplasm

References:

GO:0005815 - microtubule organizing center

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GO:0005634 - nucleus

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GO molecular function

GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0003449 - abnormal cell cycle arrest at mitotic G1/S phase transition

References:

Genotypes:

FYPO:0006838 - abnormal linear element maturation

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Genotypes:

FYPO:0001343 - abnormal mitotic DNA replication

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Genotypes:

FYPO:0001425 - abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication

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Genotypes:

FYPO:0001370 - abnormal protein localization

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

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Genotypes:

FYPO:0004077 - abnormal sporulation resulting in formation of ascus with single large spore

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Genotypes:

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

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Genotypes:

FYPO:0004798 - abolished azygotic meiosis II

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Genotypes:

FYPO:0003485 - abolished DNA synthesis

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Genotypes:

FYPO:0000514 - abolished nuclear import

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Genotypes:

FYPO:0004800 - abolished premeiotic DNA replication during azygotic meiotic cell cycle

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Genotypes:

FYPO:0004799 - abolished zygotic meiosis II

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

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Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

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Genotypes:

FYPO:0004089 - decreased meiotic recombination during zygotic meiosis

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Genotypes:

FYPO:0003189 - decreased protein import into nucleus

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Genotypes:

FYPO:0004242 - decreased protein kinase activity during mitotic S phase

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0004628 - delayed onset of premeiotic DNA replication

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Genotypes:

FYPO:0004801 - delayed onset of premeiotic DNA replication during azygotic meiosis

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Genotypes:

FYPO:0000344 - enlarged nucleus during vegetative growth

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Genotypes:

FYPO:0006841 - increased duration of meiotic S phase

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Genotypes:

FYPO:0001043 - increased mating efficiency

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Genotypes:

FYPO:0002277 - increased protein degradation during nitrogen starvation

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Genotypes:

FYPO:0000836 - increased protein level

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Genotypes:

FYPO:0004108 - increased protein level during mitotic G1 phase

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0000839 - inviable elongated mononucleate aseptate cell

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000333 - mitotic G1/S phase transition delay

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Genotypes:

FYPO:0001000 - normal cell cycle arrest in mitotic G1 phase during nitrogen starvation

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0003563 - normal meiosis I

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Genotypes:

FYPO:0001428 - normal negative regulation of mitotic DNA replication initiation

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Genotypes:

FYPO:0005650 - normal onset of premeiotic DNA replication

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Genotypes:

FYPO:0002801 - normal protein degradation during nitrogen starvation

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Genotypes:

FYPO:0003332 - normal protein kinase activity during mitotic interphase

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Genotypes:

FYPO:0000840 - normal RNA level

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Genotypes:

FYPO:0004993 - normal spore germination frequency

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein features

PBO:0111870 - B-type cyclin

PBO:0111794 - cyclin

Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000021 - protein present

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PomGeneEx:0000016 - RNA level constant

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0001974 - increased number of cells with 1C DNA content

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Genotypes:

FYPO:0000951 - inviable small vegetative cell

References:

Genotypes:

FYPO:0000333 - mitotic G1/S phase transition delay

References:

Genotypes:

FYPO:0005578 - normal intergenic meiotic recombination

References:

Genotypes:

FYPO:0000760 - normal mating

References:

Genotypes:

FYPO:0005650 - normal onset of premeiotic DNA replication

References:

Genotypes:

FYPO:0004993 - normal spore germination frequency

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002701 - sensitive to torin1

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Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00134Cyclin_NCyclin_NPFAM
PF02984Cyclin_CCyclin_C-domPFAM
cd20568CYCLIN_CLBs_yeast_rpt1CDD
cd20512CYCLIN_CLBs_yeast_rpt2CDD
PS00292CYCLINSCyclins_cyclin-boxPROSITE_PATTERNS
SM01332Cyclin_C_2Cyclin_C-domSMART
SM00385cyclin_7Cyclin-like_domSMART
G3DSA:1.10.472.10:FF:000001FUNFAM
SSF47954Cyclin-likeCyclin-like_sfSUPERFAMILY
G3DSA:1.10.472.10GENE3D
PTHR10177CYCLINSCyclinPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:11683390 - In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.
Decottignies A et al. J Cell Sci 2001 Jul;114(Pt 14):2627-40
PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.
Stonyte V et al. iScience 2020 May 22;23(5):101063
PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.
Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:8631306 - A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.
Fisher DL et al. EMBO J 1996 Feb 15;15(4):850-60
PMID:1829983 - A fission yeast B-type cyclin functioning early in the cell cycle.
Bueno A et al. Cell 1991 Jul 12;66(1):149-59
PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.
Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9
PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.
Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28
PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.
Snaith HA et al. Genetics 1999 Jul;152(3):839-51
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:32084401 - The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.
Basu S et al. Curr Biol 2020 Mar 09;30(5):883-892.e4
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:10982385 - A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
Tanaka K et al. Mol Biol Cell 2000 Sep;11(9):2845-62
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:10679013 - The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Martín-Castellanos C et al. Mol Biol Cell 2000 Feb;11(2):543-54
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:9436991 - Negative regulation of Cdc18 DNA replication protein by Cdc2.
Lopez-Girona A et al. Mol Biol Cell 1998 Jan;9(1):63-73
PMID:9353247 - Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.
Jallepalli PV et al. Genes Dev 1997 Nov 01;11(21):2767-79
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9303310 - p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.
Correa-Bordes J et al. EMBO J 1997 Aug 01;16(15):4657-64
PMID:11493649 - Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation.
Blanco MA et al. J Cell Sci 2001 Jun;114(Pt 11):2135-43
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:9430640 - Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.
Benito J et al. EMBO J 1998 Jan 15;17(2):482-97
PMID:10921876 - APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.
Blanco MA et al. EMBO J 2000 Aug 01;19(15):3945-55
PMID:8264644 - Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.
Connolly T et al. Mol Cell Biol 1994 Jan;14(1):768-76
PMID:8006074 - Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit.
Forsburg SL et al. J Cell Sci 1994 Mar;107 ( Pt 3):601-13
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871