protein coding gene - psk1 (SPCC4G3.08) - serine/threonine protein kinase S6K family Psk1

Gene summary

Standard name

psk1

Systematic ID

SPCC4G3.08

Product

serine/threonine protein kinase S6K family Psk1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q12706

ORFeome ID

50/50A06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 457709..459495 reverse strand

Annotation

Protein features

Orthologs

• RPS6KA1 (HGNC:10430) Homo sapiens
• RPS6KA2 (HGNC:10431) Homo sapiens
• RPS6KA3 (HGNC:10432) Homo sapiens
• RPS6KA6 (HGNC:10435) Homo sapiens
• RPS6KB2 (HGNC:10437) Homo sapiens
• psk1 (SJAG_01047) Schizosaccharomyces japonicus
• YPK3 (YBR028C) Saccharomyces cerevisiae

References / Literature

PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Tatebe H et al. Elife 2017 Mar 07;6

PMID:37913773 - TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation.

Hirai H et al. Cell Rep 2023 Nov 28;42(11):113320

PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.

Laor D et al. mBio 2015 Jul 07;6(4):e00959

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Hatano T et al. Cell Cycle 2015;14(6):848-56

PMID:28671615 - TORC1-Dependent Phosphorylation Targets in Fission Yeast.

Otsubo Y et al. Biomolecules 2017 Jul 03;7(3)

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:31833215 - Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.

Shetty M et al. Aging Cell 2020 Feb;19(2):e13068

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:19888300 - Coffin-Lowry syndrome.

Pereira PM et al. Eur J Hum Genet 2010 Jun;18(6):627-33

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:27876895 - Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast.

Madrid M et al. Sci Rep 2016 Nov 23;6:37515

PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:36481249 - Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe.

Panigrahi L et al. Fungal Genet Biol 2023 Jan;164:103764

PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.

Chia KH et al. Elife 2017 Dec 04;6

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:24247430 - Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.

Hálová L et al. J Cell Biol 2013 Nov 25;203(4):595-604

PMID:39910760 - Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast.

Ohtsuka H et al. Aging Cell 2025 Feb 05;:e14450

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:29330317 - tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.

Otsubo Y et al. EMBO Rep 2018 Mar;19(3)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:33534698 - Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.

Fukuda T et al. Elife 2021 Feb 03;10

PMID:34499159 - Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif.

Morozumi Y et al. J Cell Sci 2021 Oct 01;134(19)

PMID:39010328 - Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains.

Morozumi Y et al. FEBS Lett 2024 Jul 15;

PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.

Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64

PMID:22976295 - Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

Nakashima A et al. J Cell Sci 2012 Dec 01;125(Pt 23):5840-9

PMID:8529881 - Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide.

Mukai H et al. Gene 1995 Dec 01;166(1):155-9

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31641022 - The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.

Reidman S et al. J Biol Chem 2019 Nov 29;294(48):18244-18255

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.

Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531