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protein coding gene - mdj1 (SPCC4G3.14) - mitochondrial Hsp70 family DNAJ domain protein Mdj1

Gene summary

Standard name
mdj1
Systematic ID
SPCC4G3.14
Product
mitochondrial Hsp70 family DNAJ domain protein Mdj1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87239
ORFeome ID
25/25E10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 442924..445176 reverse strand

Annotation

GO biological process

GO:0042026 - protein refolding

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0001671 - ATPase activator activity

References:

GO:0031072 - heat shock protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00226DnaJDnaJ_domainPFAM
PF01556DnaJ_CDnaJ_CPFAM
PF00684DnaJ_CXXCXGXGHSP_DnaJ_Cys-rich_domPFAM
cd10747DnaJ_CCDD
cd10719DnaJ_zfHSP_DnaJ_Cys-rich_domCDD
cd06257DnaJDnaJ_domainCDD
PS00636DNAJ_1DnaJ_domain_CSPROSITE_PATTERNS
PS51188ZF_CRHSP_DnaJ_Cys-rich_domPROSITE_PROFILES
PS50076DNAJ_2DnaJ_domainPROSITE_PROFILES
SM00271dnaj_3DnaJ_domainSMART
PR00625JDOMAINDnaJ_domainPRINTS
G3DSA:2.60.260.20:FF:000005FUNFAM
G3DSA:2.10.230.10:FF:000001FUNFAM
SSF49493HSP40/DnaJ peptide-binding domainHSP40/DnaJ_pept-bdSUPERFAMILY
SSF46565Chaperone J-domainJ_dom_sfSUPERFAMILY
SSF57938DnaJ/Hsp40 cysteine-rich domainHSP_DnaJ_Cys-rich_dom_sfSUPERFAMILY
G3DSA:2.10.230.10GENE3D
G3DSA:1.10.287.110DnaJ domainJ_dom_sfGENE3D
G3DSA:2.60.260.20GENE3D
PTHR43096DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATEDPANTHER
MF_01152DnaJDnaJHAMAP
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
GO_REF:0000002 - Comments
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87