protein coding gene - alp16 (SPCC4G3.19) - gamma tubulin complex GCP6 subunit Alp16

Gene summary

Standard name

alp16

Systematic ID

SPCC4G3.19

Product

gamma tubulin complex GCP6 subunit Alp16

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P87244

ORFeome ID

28/28B12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome III: 432264..434786 reverse strand

Annotation

Protein features

Orthologs

• TUBGCP6 (HGNC:18127) Homo sapiens
• alp16 (SJAG_01756) Schizosaccharomyces japonicus

References / Literature

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:30463883 - Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe .

Yukawa M et al. G3 (Bethesda) 2019 Jan 09;9(1):269-280

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:35622906 - Distribution of γ-tubulin ring complex at the Schizosaccharomyces pombe spindle pole.

Saha S et al. MicroPubl Biol 2021;2021

PMID:15800064 - Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring.

Venkatram S et al. Mol Biol Cell 2005 Jun;16(6):3052-63

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12134075 - A fourth component of the fission yeast gamma-tubulin complex, Alp16, is required for cytoplasmic microtubule integrity and becomes indispensable when gamma-tubulin function is compromised.

Fujita A et al. Mol Biol Cell 2002 Jul;13(7):2360-73

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:17021256 - Noncore components of the fission yeast gamma-tubulin complex.

Anders A et al. Mol Biol Cell 2006 Dec;17(12):5075-93

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21993292 - Microtubule nucleation by γ-tubulin complexes.

Kollman JM et al. Nat Rev Mol Cell Biol 2011 Oct 12;12(11):709-21

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:27053664 - Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly.

Masuda H et al. Mol Biol Cell 2016 Jun 01;27(11):1753-63

PMID:15004232 - Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function.

Venkatram S et al. Mol Biol Cell 2004 May;15(5):2287-301

PMID:21444751 - Microtubule stabilization in vivo by nucleation-incompetent γ-tubulin complex.

Anders A et al. J Cell Sci 2011 Apr 15;124(Pt 8):1207-13