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protein coding gene - gpi2 (SPCC550.04c) - pig-C

Gene summary

Standard name
gpi2
Systematic ID
SPCC550.04c
Product
pig-C
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59802
ORFeome ID
17/17H05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome III: 1191599..1193192 reverse strand

Annotation

Disease association

MONDO:0040500 - glycosylphosphatidylinositol biosynthesis defect 16

References:

GO biological process

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000506 - glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

References:

GO molecular function

GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF06432GPI2Plno_GlcNAc_GPI2PFAM
PTHR12982PHOSPHATIDYLINOSITOL GLYCAN, CLASS CPlno_GlcNAc_GPI2PANTHER
PIRSF016104PIG-CPlno_GlcNAc_GPI2PIRSF

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405